Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
21 Cards in this Set
- Front
- Back
|
spirochetes gen
|
spirochetes gen:
- slender, spiral - poorly G stain - actively motile - differentiation: morphology, Ag prop - dark-field microscopy, serology - Leptospira, Brachyspira, Borrelia |
|
|
spirochete morphology
|
spirochete morphology:
- wider waves, fatter: borrelia> serpulina (treponema)> leptospira |
|
|
Leptospira spp
|
Leptospira spp:
- need special broth media, BA no use - several spp: 1. biflexia: non-pathogenic 2. interrogans: most pathogenic serovars eg icterrohemorrhagiae, canicola, pomona, grippotyphosa 3. borgpersenil: a few pathogenic serovars - in practice only serovars used eg L. pomona |
|
|
Leptospira habitat
|
Leptospira habitat:
1. kidneys--> urine: lifetime 2. water contaminated w/ urine: for weeks-months 3. maintenence / reservoir host: (accidental), rodent for several serovars |
|
|
Leptospira pathogenesis
|
Leptospira pathogenesis:
1. entry: mucous mem, damaged skin 2. blood 3. spleen, liver 4. damage vascular epithelium, hepatocytes: jaundice 5. most killed by body 6. survivors: multiply in convoluted tubules--> urine |
|
|
Lepto clin signs in cattle, pigs
|
1. fever
2. anemia: hemolysis 3. icterus 4. hemoglobinuria 5. infertility, abortion, weak offspring - bovine: hardjo - both: pomona, icterhemorrhagiae |
|
|
Lepto clin signs in dogs
|
Lepto clin signs in dogs:
- most cases mild or subclinical 1. acute: fever, hemorrhage, icterus, death - icterohemorrhagiae 2. less acute: anemia, anorexia, hepatitis, fever - icterohemorrhagiae 3. uremic: chronic interstitial nephritis= oliguria, anuria, renal failure - canicola |
|
|
Lepto clin signs horses, etc
|
Lepto clin signs horses:
- uncommon 1. abortion 2. periodic opthalmia: recurrent conjunctivitis, iridocyclitis--> blindness - may be cause by HS Type III - bratislava -- cats: clin dz not seen -- humans: flu-like, rarely orchitis |
|
|
Lepto dx
|
Lepto dx:
1. urine sample: dark field microscopy 2. FA: urine sediment, tissues 3. serology: microscopic agglutination, ELISA 4. culture special media: body fluids 5. PCR: doesn't ID serovar |
|
|
Lepto control
|
Lepto control:
1. vaccs: should contain Ag of local serovars - dogs: canicola, icterohem, pomona, grippotyphosa - pigs: + Erysipelas 2. rodent control 3. fence off ponds, streams 4. screen replacement stock 5. Pen, Strep, Tetra, Doxy for dogs |
|
|
Treponema
|
Treponema:
- pallidum: human syphillus - parluis-cuniculi: rabbit syphillus |
|
|
Brachyspira
|
Brachyspira:
- hyodysenteriae: swine dysentery - other spp less important |
|
|
swine dysentery
|
swine dysentery:
- B hyodysenteriae: anaerobic, O2 tolerant - dz limited to intestine |
|
|
swine dysentery pathogenesis
|
swine dysentery pathogenesis:
1. carrier: pigs, temporarily rodents 2. fecal-oral infection 3. colonic goblet cell infection 4. mucous secretion, cell proliferation 5. muco-hemorrhagic colitis 6. blood/mucous feces, colonic malabsorption 7 dehydration, acidosis |
|
|
swine dysentery transmission
|
swine dysentery transmission:
- organism can survive in anaerobic pits, fences contaminated w/ feces - rodents: temporary carriers |
|
|
swine dysentery dx
|
swine dysentery dx:
1. clin signs 2. India ink negative, wet mount, G or Giemsa stain: feces, colon contents 3. culture: BA, anaerobic 4. PCR: less sensitive 5. serology: limited use |
|
|
swine dysentery control
|
swine dysentery control:
1. prophylactic, tx feed of antibiotics: Tylosin 2. sanitation, disinfection concurrently, rest for 60 days so organisms can die off 3. replacement pigs: from known source, quarantine, meds |
|
|
Borrelia burgdorferi pathogenesis
|
Borrelia burgdorferi pathogenesis:
- Lyme dz: imp in dogs 1. tick transmission 2. multiplication 3. inflammatory response 4. blood invasion 5. musculoskeletal system, heart, CNS 6. accum in synovial fluid 7. arthritis |
|
|
Lyme clin signs in dogs
|
Lyme clin signs in dogs:
- only 5% infected show signs 1. fever 2. polyarthritis, lameness 3. rarely nephritis: often fatal - humans: erythema chronicum migrans (ECM) |
|
|
Lyme dx
|
Lyme dx:
1. history of tick exposure, signs, response to antibiotics 2. serology: IFA, ELISA 3. Giemsa, FA, dark field: body fluids |
|
|
Lyme tx, control
|
Lyme tx, control:
- doxy, tetra, etc x 4 weeks - vacc: outer sheath Ag (ospA), old bacterins - tick control, bite prevention |
