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19 Cards in this Set
- Front
- Back
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Example of an anti-inflammatory mediator.
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IL-10
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Unregulated systemic inflammation is called ________.
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Sepsis
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O-Antigen vs Lipid A
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O-antigen is antigenic (diverse) part of LPS Endotoxin on Gram Neg bacteria
Lipid A is toxic component (mediates INFLAMMATORY RESPONSE) |
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How does immune response when:
Low levels LPS High levels LPS |
Low levels: mild inflamm respo like fever, mac actvn
Higher levels LPS: TNF-ALPHA released, get coagulation, damage, organ failure |
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Significance of lipooligosaccharide?
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LOS!
Neisseria doesn't have an O region, instead has LOS |
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What medium does neisseria grow on?
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Thayer-Martin (CHOCOLATE)
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Why is neisseria considered an obligate human pathogen?
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Because it can't survive without human iron
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What does neisseria look like under the microscope?
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scrotum
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Gene Conversion vs Phase Variation
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Employed by NEISSERIA PILI:
gene conversion: move geners before/after promoter phase variation: reading frama of pili genes changed |
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LOS sialation: purpose
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Used by NEISSERIA gonorrhea, which is UNENCAPSULATED
so it steals sialic acid from the host, encapsulates itself in that ish, and then the host thinks it's host! |
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Is gonorrhea motile?
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No, spreads locally
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Arthritis can indicate prior _______ infection.
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Gonococcal (goes to synovial fluid)
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Disseminated Coagulation (in infants) is associated with ______
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neisseria meningitidis
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How does N. meningitidis differ from N. gonorrhea?
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N. meningitidis HAS A CAPSULE
(both secrete IgA proteases) |
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This bacterium has polar flagella.
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Pseudomonas
also, it's a ROD |
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What bacterium exhibits pyocyanin? Clinical manifestations?
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Polycyanin = Pseudomonas
GREEN PIGMENT GREEN WOUNDS (grape/fruity odor) |
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What patients are susceptible to pseudomonas?
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IC'd (CYSTIC FIBROSIS, cancer, AIDS, transplant)--it's ubiquitous btw
PSEUDOMONA IS ENCAPSULATED FYI |
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Hot tub folliculitis is associated with _________
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pseudomonas
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Burn infections are associated with _________
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pseudomonas
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