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15 Cards in this Set
- Front
- Back
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What are the 2 FLU drugs?
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-Amantadine
-Oseltamivir |
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What is Amantadine used for?
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Influenza A prophylaxis
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When does Amantadine have to be given if you want it to have a therapeutic effect on Influenza A? What effect will that be?
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Within the 1st 2 days of symptom onset; will reduce fever in 50% of patients and shorten illness duration by 1-2 days
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What is Amantadine's mechanism?
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Blocks viral uncoating by interfering with Infl A M2 protein (ion channel)
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How is Amantadine administered? How is it eliminated?
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Oral administration
Eliminated unchanged by kidneys |
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So what do you have to be careful of when giving Amantadine?
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Renal disease - would need to lower the dose
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Though Amantadine is generally well tolerated, what are its main side effects?
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-CNS side effects - Headache, anxiety..
-Nausea/vomiting |
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What is the mechanism of action of Oseltamivir?
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Prodrug competitive inhibitor of influenza's neuraminidases.
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What does inhibition of neuraminidase result in?
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Inhibition of viral release from infected cells and viral penetration into resp epithelium
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Where is Oseltamivir converted from its prodrug form to the active form?
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In the liver by esterases
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What are the 2 uses of Oseltamivir?
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-Treatment of uncomplicated Influenza A/B in children 1 yr or older if given in 48 hrs of onset
-Prophylaxis in patients 1yr old or more |
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How is Oseltamavir administered?
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Orally
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How is Oseltamavir eliminated?
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By the kidney
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What are 3 side effects of Oseltamivir?
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-Bronchitis!!!!
-Nausea/vomiting -Diarrhea |
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Which drug will likely be effective in treating and preventing Avian bird flu infection?
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Oseltamivir
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