194-Exam3-Chapter 34-Drugs Affecting Immune Response

Front 1

Interferon alfa-2a
1-treats
2-C/I
3-adverse
4-Nurse
5-teach pt
6-drug interactions

Back 1

Inhibits the growth of tumor cells,Prevents multiplication,Increases the immune response, blocks viral infections,
1- Some types of Leukemias,AIDS related Kaposi sarcoma.
2 Pancreatitis,Hepatic or renal disease,Depressed Bone marrow,Cardiac disease or Compromised cns. Preg-C
3- Dizziness,confusion,lethargy,flu-like symptoms, anorexia,nausea and taste changes,Depression,anxiety,Suicidal ideation, Hypothyroidism,hyperand hypotension,Depression of BM,Rash,Alopecia,Glucose intolerance.
4- Risk for infection,nutrition (less),treat for drugs like,acetaminophen&diphenydramine for the flu like symptoms with the int alpha.
5- explain the action, reconstituting administering and storing the soln (30 days) rotate the inj site and sterile techniques,neuropsychiatric effects.avoid infection, injury,and any change in the general health, like fever mental disturbances.
6- Theophylline toxicity,cimetidine,vinblastin.

Front 2

Rituximab

1-treats
2-C/I
3-adverse
4-Nurse
5-teach pt
6-drug interactions

Back 2

Binds to CD20 ag on the surface of mallignant B lymphocytes and causes cell lysis.

1-Non Hodgkin's lymphoma, Rheumatoid Arthritis,Autoimmune disease, multiple myloma, post transplant, ch leukemia.
2 Type 1 hypersensitivity or anaphylaxis to Murine protiens, fetal reactions, pregnant or breast feeding and not tested.
3 Infusion related effects: fever, chills, flushing rigors etc
Serious; hypotension and respiratory distress..
4 administer in saline or dextrose in plastic bags, not glass., premedicate the pt.Slow infusion.and close monitoring for the first dose reactions.
5 consume large amounts of water, birth control, follow up visits for the blood chem and lab parameters for tumor lysis syndrome.
6 concomitant Vaccines for interactions with the drug.

Front 3

Cyclosporine
1-treats
2-C/I
3-adverse
4-Nurse
5-terach pt
6-drug interactions

Back 3

Immunosuppressant Inhibits the T lymphocytes.
1 prevent rejection in solid organ transplant, prevent graft versus host disease in allogenic (donor other than self) bone marrow transplant.or stem cell transplant.
2 hypersensitivity to polyexyethylated castor oil.no UV A /B with oral ,Preg- C
3 renal and hepatic toxicity.
renal dysfunction, hirsutism,hypertensionand gum hyperplasia, brittle nails pruritus,conjunctivitis,thrombocytopenia,night sweats joint pain etc.
4 oral drug within 30 mins of foood,part high fat meal, decreases the drug effect,no grapefruit juice, not be refrigerated.
5 pt education about the administration, avoid the infections and sunlight.and care for preg and children.
6 aminoglycosides, nifedipine,rifampine.

Front 4

Cetuximab
1-treats
2-C/I
3-adverse
4-Nurse
5-teach pt
6-drug interactions

Back 4

Chimeric monoclonal ab,targets the EGFR site of the cell and can deprive the cell of cytokines and ligands necessary for growth and metabolism.
1 monotherapy or combination with irinotecan for EGFR colorectal ca squamos cell ca of head and neck.
2
3 rash, acne like, dry skin, dose limiting toxicity,bronchospasm urticaria and hypotension.
4 2hr loading dose,1hr weekly infusion.in line filter used, monitor magnesium levels.

Front 5

rituximab
life span alert

Back 5

use birth control during therapy and for a year afterward and avoid breast feeding during this time with caution in older adults.

Front 6

Rituximab

Back 6

Shake and bake.
fever and chills

Front 7

cyclosporine

Back 7

take it same time everyday,
use glass container not plastic,
use the syringe not the tblspoon, it will alter the dose,

Front 8

Interferon alpha

Back 8

Hairy cell leukemia,philadelphia chromosome positive ,cutaneous warts ,condylomata, malignant melanoma, Hep C.