19 Pharm - Skeletal Muscle Relaxants

Front 1

Structurally related to acetylcholine, used to produce muscle paralysis in order to facilitate surgery or artifical ventilation. Full doses lead to respiratory paralysis and require ventilation

Back 1

Neuromuscular blocking drugs

Front 2

These drugs strongly potentiate and prolong effect of neuromuscular blockade (NMB)

Back 2

Inhaled anesthetics, especially isoflurane, aminoglycosides, and antiarrhythmic

Front 3

These prevent the action of Ach at the skeletal muscle endplate to produce a "surmountable blockade," effect is reversed by cholinesterase inhibitors (ex. neostigmine or pyridostigmine)

Back 3

Nondepolarizing type antagonists

Front 4

Agent with long duration of action and is most likely to cause histamine release

Back 4

Tubocurarine

Front 5

Non-depolarizing skeletal muscle antagonist that has short duration

Back 5

Mivacurium

Front 6

Skeletal muscle agent that can block muscarinic receptors

Back 6

Pancuronium

Front 7

Skeletal muscle agent that undergoes Hofmann elimination (breaks down spontaneously)

Back 7

Atracurium

Front 8

One depolarizing blocker that causes continuous depolarization and results in muscle relaxation and paralysis, causes muscle pain postoperatively and myoglobinuria may occur

Back 8

Succinylcholine

Front 9

During Phase I these agents worsen muscle paralysis by succinylcholine, but during phase II they reverse the blockade produced by succinylcholine

Back 9

Cholinesterase inhibitors