Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
14 Cards in this Set
- Front
- Back
|
How does the body handle drugs?
|
A - absorption
D - distribution E - elimination M - metabolism |
|
|
Absorption of drugs is affected by what?
|
1)First Pass Metabolism
2)Blood Flow at Site of Administration 3)Demographic Features |
|
|
Vd or apparent volume of distribution is calculated how?
|
Amount of drug in body / Concentration in Plasma
|
|
|
A High Vd signifies what?
|
Lipophilic, stored in fatty tissue
|
|
|
A Low Vd signifies what?
|
Hydrophilic, stays in plasma, alot is eliminated without metabolizing
|
|
|
What is First Order Kinetics?
|
Exponential Elimination
1/2 Life System (Vd) / (t1/2) |
|
|
What is Zero Order Kinetics?
|
Linear Elimination
No 1/2 Life Alcohol: The more you take, the long it takes to leave |
|
|
What is the effective dose?
|
Amount of Drug that produces a theaurputic effect, in 50% of test population
|
|
|
What is the toxic dose?
|
Amount of Drug that shows poisoning
|
|
|
What is the safe dose?
|
Somewhere between effective and toxic
|
|
|
What is efficacy of drug?
|
The effect once the drug is bound
|
|
|
What is the affinity of drug?
|
How well it binds receptors
|
|
|
Cholinergic Agonists:
Direct Acting Pilocarpine / Carbachol |
Inc Aqueous Outflow
|
|
|
Cholinergic Agonists:
Direct Acting Bethanechol |
Treatment of Urinary Retention by acting on smooth mm in bladder
|
