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4 Cards in this Set
- Front
- Back
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What is the margin of safety?
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The difference between the toxic dose and the effective dose.
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How are Phase I and Phase II products excreted?
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Phase I products that can be excreted do so through the kindney; Phase II products are excreted through the GI tract via the bile duct (more common pathway for lipid soluble chemicals).
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Why can grapefruit juice contribute to a toxic effect with some drugs?
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Grapefruit juice inhibits CYP3A4 creating a lower first pass effect and a greater concentation of a drug metabolized by this pathway.
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Where does drug metabolism take place?
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Enzymes are generally synthesized in the RER and metabolism occurs in the SER.
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