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27 Cards in this Set
- Front
- Back
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Platelets
last? originate? |
4-7 days
megakaryocytes |
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Platelets are responcible for bleeding?
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skin and mucosal surfaces
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Deficiency of platelets leads to?
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petechia purpura ecchymoses
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MCC of Thrombocytopenia
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1 Viral (Parvo b19, Hep B/C)
2 Drugs (AZT, Benzene, Chloramphenicol, Vinblastine) |
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Treatment of autoimmune throbocytopenia
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Normal 150-350
<40K steroids <20K plasmapheresis /IV gammaglobulins <10K splenectomy |
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ITP what is happening who gets it?
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platelet ab,
two weeks after UTI prelude to SLE children resolves adults chronic |
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TTP pentad?
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Fever, Thrombocytopenia, Microangiopathic Hemolytic Anemia, Neurologic symptoms, RF
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Clotting factors stop bleeding?
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into cavities
Intracranial, mediastinal, pleural, pericardium, abdominal, pelvis, retroperitoneum, thighs |
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Intrinsic clotting system is
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ALL follow PTT
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Extstrinsic clotting system is
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7 follow PT
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Adhesion to exposed BM
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requires vWF
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Aggregation regulated by
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increases aggregation: TXA
dec agg: PGI and NO |
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Swelling
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ADP + Ca --> fibrin deposits
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Bernard Soulier syndrome
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defect glycoprotein 1B
BIG PLATELETS |
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Glanzman's Thrombesthenia
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Congenital absence of glycoprotiens
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Vit K cofactor for, and makes factors
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Gamma Carboxylation,
(1972) protien C & S |
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Warfarin
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blocks K, protein C first to go (6hr h/l) next 7 (2d h/l) Follow PT (INR 2-3xNL)
Reverse, Vit K or FFP |
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Von Willebrand's Dz, what is it? labs? Tx?
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AD, VWF anchors VIII to platelets,
elevated PTT and BT. mild- DDAVP mod- cryoprecipitate sev- FFP |
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Hemo A what is it? labs? Tx
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F-8: X linked, bleeding into cavities.
follow PTT mild- DDAVP mod- cryoprecipitate sev- factor 7 concentrate |
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Hemo B what is it? labs? Tx
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F-9 def, X linked, bleeding into cavities
follow PTT Tx FFP |
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Dysfibrinogenemias?
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clot falls apart after 2 hours
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Fibrin stabilization factor deficiency?
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recurrent umbilical stump bleeding, tx FFP
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How does the body break up a clot?
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1) Antithrombin III activated by heparin inactivates: 9a-10a-11a
2) Protein C inactivates 5a-7a |
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#1 cause of clott formation
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Factor V leiden, thrombotic events under the age of 45. Protien C can't see him.
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Converts plaminogen to plasmin? tx OD?
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tpa, streptokinase, urokinase
tx aminocaproic acid |
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Platelet abnormality?
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Micohemorrhages: mucosal membranes, petechia, purpura
INC BLEEDING TIME |
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Coagulation factor abnormality?
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Macrohemorrhages: hemarthrosis, bruises
INC PT, PTT |
