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17 Cards in this Set
- Front
- Back
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5 classes of diuretics
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- Osmotics
- Carbonic anhydrase inhibitors - Loop diuretics - Aldosterone antagonists - K sparing diuretics |
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What are osmotics?
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Non-resorable sugars
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Which part of the nephron do osmotics effect?
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PT
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How do osmotics function?
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Trap water in the PT by osmosis
- Excess water dilutes Na+ gradient and results in less reabsorption |
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Site of action for carbonic anhydrase inhibitors (2)
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- PT
- LoH |
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Mechanism of carbonic anhydrase inhibitors
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Inhibit formation of carbonic acid
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Result of carbonic anhydrase inhibitors
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Loss of free H+ prevents operation of apical Na-H antiporter, reducing reabsorption of Na+
- Increases Na+ and H2O excretion |
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Site of action for loop diuretics
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LoH
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Fxn of Loop diuretics
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Inhibits lumenal Na-K-Cl symporter
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Site of action for Aldosterone antagonists
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DT/CD
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Fxn of aldosterone antagonists
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Inhibit aldosterone's ability to bind to its receptor in DT/CD cells
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Result of aldosterone antagonists
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Inhibits aldosterone's ability to stimulate Na+ reabsorption
- Also works on K+ secretion |
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What do aldosterone antagonists double as?
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K+ sparing diuretics
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What is a potential side effect of long-term diuretic usage?
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Hypokalemia
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Site of action of K+ sparing diuretics
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DT
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Mechanism for K+ sparing diuretics
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Block lumenal Na+ channels in DT, reducing negative charge normally present from Na+ reabsorption
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Result of K+ sparing diuretics
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Reduces driving force for K+ secretion (the negative charge present in Na+ reabsorption)
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