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19 Cards in this Set
- Front
- Back
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In the synthesis of Serine and Glycine, what serves as the one carbon carrier in this pathway?
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Tetrahydrofolate (H4 folate)
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Amino acids who's catabolism yield Pyruvate or intermediates of the TCA are termed:
Those that yield Acetoacetate, AcetylCoA or AcetoacetylCoA are termed: |
Glucogenic
Ketogenic |
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What are the only two aa's that cannot give rise to precursors of gluconeogensis and are therefore strictly ketogenic?
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Leucine and lysine
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What two enzymes generate on carbon units via tetrahydrofolate? (p323)
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Serine-hydroxy-methyl transferase. Glycine cleavage enzyme.
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What is the reduced form of folate?
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Tetrahydrofolate
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Tetrahydrofolate is required for the synthesis of what two aa?
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Serine and Glycine
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What co-enzyme does Serine Hydroxymethyl Transferase require?
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PLP
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What is the major aa used to donate a carbon unit to the folate pathway? (p324)
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Serine
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5-Me-THF is used to synthesize methionine. The enzyme mediating this rxn is: It requires this vitamin (p324)
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Methionine Synthase
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What does SAM - S-adenosyl-methionine donate? (p326)
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Methyl groups.
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Once SAM gives up its methyl group, it becomes:
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SAH: S-adenosyl homocysteine.
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What is spina bifida or anencephaly caused by (2 things)?
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SAM or Vitamin B12 deficiency
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Excess methionine is degraded to: (p327)
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Succinyl-CoA
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What are the 3 precursors of Purines?
What are the two precursors of Pyrimidines? |
Purines: Aspartate + Glycine + Formate
Pyrimidines: Aspartate + Carbamoyl-P |
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Deficiency in what causes thin elongated long bones, osteoporosis, scoliosis, lens dislocation?
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Cystathionine-B-synthase, causing Homocysteinuria
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Arginine is converted to ?? and ?? by nitric oxide synthase? What is an essential co-factor in this reaction?
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Nitric Oxide
Citrulline Essential co-factor = tetrahydrobiopterin |
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Glutathione is synthesized from three amino acids: (p329)
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Glutamate, Cysteine, Glycine
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Histidine can be decarboxylated to form: The enzyme used is: And it requires this co-factor
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1. Histidine
2. Histidine Decarboxylase 3. PLP |
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Glutamate will be converted to: via Glutamate decarboxylase - an enzyme the requires this.
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1. Gamma-aminobutyrate
2. PLP |
