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10 Cards in this Set
- Front
- Back
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What makes ethanol a good drug? |
It is soluble in both water and lipids, small, not charged, not subject to pH changes, and passes easily through lipid membrane barriers |
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What impacts ethanol absorption? |
The rate of consumption, volume consumed, presence of carbonation, presence of food in stomach, medication impacting GI motility |
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What percent of drug metabolism occurs in the liver? |
95% |
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Up until what concentration do first order metabolism kinetics occur? |
10 mg/dL |
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After what concentration do zero order kinetics occur? |
10 mg/dL |
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What is the rate-limiting step of converting ethanol to acetaldehyde? |
NAD+ to NADH |
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What chemical produces 'hangover' effects? |
Acetaldehyde from ethanol metabolism |
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What is the ratio of breath alcohol to blood alcohol? |
2100:1 |
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What receptors have been targeted if sedative effects are seen? |
GABA receptors, glycine receptors |
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What receptors have been affected if ataxia and nausea are seen? |
Acetylcholine receptors |
