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17 Cards in this Set
- Front
- Back
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Type 1 Collagen:
Structure |
Gly-XY??
Triple helix structure |
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OI:
Mutation |
Mutation in Type I collagen
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These cells make type I collagen.
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Osteoblasts
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What do osteoclasts release?
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Alkaline phosphatase
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Wolff's Law
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Form follows function
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Osteopetrosis:
Pathophys Tx |
Nonfnal or absent osteoclasts
Leads to dense, calcified bone that's not turning over-->brittle bone Curable w/BM transplant |
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Giant Cell Tumor:
Pathophys |
Overactive osteoclasts-->cavities in bone
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Five cancers that spread to bone.
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PT Barnum Loves Kids
Prostate Thyroid Breast Lung Kidney |
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Osteoporosis vs Osteomalacia
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Osteoporosis: Less overall bone mass, but proportion of bone content is the same
Osteomalacia: normal bone mass, but less mineral in bone (normal amounts of collagen, osteoid) Both are osteopenic :) |
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How does bone mass change with age? Why?
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Bone mass decreases with age because osteoblasts can't keep up with osteoclasts :'(
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Bone mass cut off for osteoporosis.
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at least -2.5 SD
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What determines bone mass?
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Genetics
Age, Sex Diet Exercise Tobacco, caffeine DM, hypothy, hyperpara, low testosterone |
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Overactive osteoblasts can result in _____.
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Bone forming tumors
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Creeping substitution is seen in _______.
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Avascular necrosis
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Avascular necrosis:
Etiology |
Idiopathic
EtOH Steroids Clotting disorder, SICKLE, Gaucher's dz Fractures, dislocation |
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Geriatric hip fracture:
Most common site of fracture |
45% Femoral neck
45% intertrochanteric |
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Why are interotrochanteric fractures more likely to heal?
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Cancellous bone, more vascularized than other regions
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