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57 Cards in this Set
- Front
- Back
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Polymyositis:
Dx criteria |
Symmetrical proximal muscle weakness
No dysphagia, no resp mm weakness Elevated CK (aldolase, ALT, AST, LDH--AST/ALT located in muscle too!) EMG Muscle bx |
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Dermatomyositis:
Dx criteria |
Symmetrical proximal muscle weakness
No dysphagia, no resp mm weakness Elevated CK (aldolase, ALT, AST, LDH--AST/ALT located in muscle too!) Muscle bx |
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Heliotrope rash
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Dermatomyositis (heliotrope = lavender)
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T cells involved in dermatomyositis and polymyositis.
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CD4+ in DM
CD8+ in Polymyositis |
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Extramuscular involvement of dermatomyositis/polymyositis.
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Constitutional syx (fatigue, wait loss, Raynaud's)
Dysphagia*** Pulm*** (respiratory mm weakness) |
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Fibromyalgia:
Presentation |
Widespread musculoskeletal pain
No inflammation on exam Normal labs NO WEAKNESS |
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Polymyalgia Rheumatica:
Presentation |
Proximal mm myalgias and stiffness
NO weakness Morning stiffness >1 hr Duration syx >2-4 hrs Anemia High ESR >40 |
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Patients with this condition should be evaluated for temporal arteritis.
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Polymyalgia rheumatica
TA can leadt to scalp tenderness, visual changes, jaw claudication |
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ANCA tests
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Vasculitis
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In vasculitis, C-ANCA is _____.
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Diffuse throughout cytoplasm
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In vasculitis, P-ANCA is ________.
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Perinuclear
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CCP is associated with ________.
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RA
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Anti-topoisomerase I is associated with _________.
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Diffuse scleroderma
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Anti-synthetase is associated with _______.
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ILD
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Anti-dsDNA is associated with _______.
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SLE GN
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SS-A is associated with _______.
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Congenital heart block (neonatal lupus!)
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Anti-centromere is associated with _______.
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Limited scleroderma (CREST syndrome)
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This disorder is female:male 9:1.
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SLE
Sjögren's |
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This involves beta-adrenergic receptors.
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vasodilation
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This involves PDGF.
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Pro-fibrotic state
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Type B synoviocytes
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Fibroblast like
(type A are like macs) |
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This is avascular.
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Articular cartilage
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Anti-phospholipid is associated with ______.
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Thrombosis
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CCP is associated with ______.
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Early RA
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Proximal muscle pain and stiffness is associated with _______.
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Polymyalgia rheumatica
(old, stiff, high SED rate, responds to low dose prednisone) |
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Plantar fascitis is associated with ________.
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Enthesitis
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Negatively birefringent is associated with ______.
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Uric acid crystles
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Conjunctivitis is associated with ______.
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Reactive arthritis
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Esophageal dysmotility is associated with _________.
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Polymyositis
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Parotid enlargement is associated with ________.
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Sjögren's Syndrome
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Syndesmophytes is associated with _________.
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Ankylosing spondyltis
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Nail pitting is associated with _________.
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Psoriatic arthritis
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Keratoderma blennorrhagicum is associated with _________.
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Reactive arthritis
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Libman Sacks endocarditis is associated with _________.
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SLE
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Subcutaneous calcinosis is associated with _________.
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Scleroderma
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Ischemic optic neuropathy is associated with _________.
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Giant cell arteritis (temporal)
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Sicca is associated with _________.
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Sjogren's
Note: Sicca = eye dryness |
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Estrogen is associated with _________.
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Uricosuric (inc'd excretion of urea in urine)
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Malignant hypertension is associated with _________.
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Diffuse scleroderma
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Salmonella infection is associated with _________.
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Reactive arthritis
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Subcutaneous nodule is associated with _________.
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RA
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HGPRT deficiency is associated with _________.
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Hyperuricemia
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TNF-alpha is associated with _________.
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Induces COX-2 (INFLAMMATION)
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IL-1 receptor antagonist is associated with _________.
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Naturally occurring anti-inflammatory cytokine
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TGF-beta is associated with _________.
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Pro-fibrotic
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Shared epitope is associated with _________.
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5 amino acid sequence--near Ag binding grooce; assocd w/RA
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IL-6 is associated with _________.
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enhances Ig synthesis (b cells-->plasma cells)
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Role of MMP.
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Degrades collagen and proteoglycan matrix
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Inflammasome is associated with _________.
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Activated by uric acid crystals
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HLA-DR4
Synovitis |
RA
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HLA-B27
Dactylitis |
Psoriatic arthritis
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Elevated ESR
Headachea |
Giant cell arteritis
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Elevated CPK
Gottrons plaques |
Dermatomyositis
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Multiple tender points
Insomnia |
Fibromyalgia
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Effects of TNF-alpha/IL-1 on:
Macrophages Endothelium Hepatocytes Synoviocytes |
Macs-->inc'd inflammn via pro-inflamm cytokines
Endothelium: Inc'd cell infiltration via inc'd adhesion molecs Inc'd angiogenesis via inc'd VEGF Hepatocytes: inc'd CRP in serum via inc'd acute phase response Inc'd articular cartilage degradation via inc'd MMP |
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This is the cause of a human bite infection.
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Eikenella
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Pain is out of proportion in this syndrome.
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Compartment syndrome
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