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8 Cards in this Set
- Front
- Back
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Five Clostridium species?
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botulinum, tetani, difficile (p.colitis), perfringens (gas gangrene), septicum (gangrene in cancer)
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Terminal spore is?
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Identifying feature of Clostridium tetani (tennis racket shape)
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Tetanus symptoms? Incubation period? Got fever? Got numbness?
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Violent spastic paralysis esp flexors, locked jaw, arched back, respiratory failure. No fever. No sensory deficit. Incubate 4 days to weeks.
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Tetanus diagnosis? Culture or not?
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diag is mostly clinical, no culture since organism rarely seen in wound site
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Tetanus toxin's subunits and mechanism?
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Has two subunits, one binds to neuronal ganglioside, the other inhibits release of glycine/GABA. Affects mainly anterior horn cells.
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How many toxin types for each kind of Clostridium?
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Tetani: just one. Botulism: many (7). Difficile: two (A and B). Perfringes: many.
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Tetanus source and frequency?
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Spores in soil enter puncture wounds and germinate when anaerobic (dirty and deep wound)
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Tetanus immunization schedule?
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Toxoid (= formaldehyde inactivated toxin), given as part of DTaP vaccine: 2, 4, 6,15-18 months, 4-6 yr (before school entry), and booster every 10 yr
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