13 Path 590-620 Path

Front 1

viruses associated with lymphoma

Back 1

HTLV-1 (human t-cell leukemia virus-1). EBV. KSHV/HHV-8

Front 2

chronic immune stimulation lymphomas?

Back 2

h pylori cause B cell.

sprue - Tcell

HIV causes B cell and by extension KSHV causes B cell

HTLV-1 Tcells (CD4+)

Front 3

starry sky?

seen in?

Back 3

macrophages ingesting apoptotic tumors cells - seen with rapidly growing lymphoid tumors

burkitt
ALL

Front 4

lymphoblast vs myeloblast

Back 4

L - more condensed chromatin, less conspicuous nucleoli and smaller amount of cytoplasm that usually lacks granules. but anitbodies against antigens are definitive test

Front 5

CD10, TdT, CALLA

Back 5

ALL

Front 6

CD10 neg and TdT positive

Back 6

T cell ALL

Front 7

ALL B cell meta

Back 7

testicles and CNS

Front 8

ALL t cell meta

Back 8

anterior mediastinal mass

Front 9

good prog for ALL?
bad?

Back 9

G - t(12;21), 2-10, hyperploidy, trisomy

B- philly chromosome , less and 2 or greater than 10,

Front 10

gene for Tcell ALL

Back 10

NOTCH1

Front 11

proliferation centers seen in?

Back 11

CLL/SLL (larger activated lymphocytes that often gather in loose aggregates)

Front 12

smudge cells see in?

Back 12

CLL/SLL - small round lymphocytes seen in peripheral blood that have scant cytoplasm. they are disrupted during smears.

Front 13

richter's transformation

Back 13

(RS) is a complication of B cell chronic lymphocytic leukemia (CLL) or hairy cell leukemia (HCL) in which the leukemia changes into a fast-growing diffuse large B cell lymphoma

lots of promyelocytes seen

Front 14

centrocyte and centroblast? seen in?

Back 14

cyte- small cells with irregular nuclear contours and scant cyto

blast - larger cells with open nuclear chromatin, several nucleoli and modest amounts of cytoplasm

follicular lymphoma

Front 15

splenic white pulp and hepatic portal triads frequently involved with?

Back 15

follicular lymphoma

Front 16

BCL2 gene

Back 16

follicular lymphoma

Front 17

BCL-6. what and which?

Back 17

repressed germinal B cell differentiation and growth, and thereby holds cells in relatively undifferentiated and proliferative state.

diffuse large B-cell lymphoma

Front 18

presents as rapidly enlarging mass at nodal or extranodal site. waldeyer ring involved frequently.

Back 18

diffuse large b-cell lymphoma

Front 19

tumor with high mitotic index and contains numerous apoptotic cells. stary sky pattern seen in phags

Back 19

burkitt lymphoma

Front 20

translocation of the c-MYC gene on chromosome 8

Back 20

burkitt lymphoma

Front 21

c-MYC induced by?

Back 21

AID - activation-induced cytosine deaminase

AID required for Ig class switching

Front 22

free light chains excreted in urine? seen in?

Back 22

bence-jones proteins. plasma cell neoplasms

Front 23

high IgM levels lead to hyperviscosity of the blood

Back 23

waldenstrom macroglobulinemia

Front 24

myeloma cells dependent on what cytokine

Back 24

IL-6

Front 25

causes skeletal probelms, increased osteoclast action with hypercalcemia and fractures

Back 25

multiple myeloma

Front 26

rouleaux formation

Back 26

MM

Front 27

B cell neoplasm that where they show some differentiation into plasma cells

Back 27

lymphoplasmacytic lymphoma

Front 28

Ig inclusions of cytoplasm or nucleus

Back 28

C - russell
N - dutcher

Front 29

flame and mott cells

Back 29

F - fiery red cytoplasm
M- mutiple cyto droplets of Ig and cells containing a variety of other inclusions]

seen in plama lymphos

Front 30

plasma cell component secrets large amounts of monoclonal IgM

Back 30

lymphoplasmacytic lymphoma.

Front 31

CD20 and high IgM

Back 31

lymphoplasmacytic lymphoma

Front 32

b cell tumors that arise within lymph nodes, spleen, and extranodal tissues

Back 32

marginal zone lymphomas

Front 33

extra nodal tissues with marginal zone lymphoms

Back 33

salivary - sjogren. thryoid in hashimoto. tomach in h pylori

Front 34

splenomegaly without lymphadenopathy. attacks middle aged men

Back 34

hairy cell leukemia

Front 35

human T-cell leukemia retrovirus (HTLV-1) encodes protein called Tax which activates NF-kappaB which enhances lymphocyte growth and survival

Back 35

adult t-cel leukemia (HTLV-1)

Front 36

adult t-cell leukemia infected by what?

Back 36

HTLV-1 attacks CD4+ cells

Front 37

horseshoe shaped nuclei and voluminous cyto

Back 37

ALK (anaplastic large cell lymphoma)

Front 38

reed-sternberg cells seen in what?

Back 38

hodgkin lymphoma

Front 39

reed-sternberg cells derived from?

Back 39

B cells

Front 40

reed-sternberg cells characteristics?

Back 40

large cells
multiple nuclei or single nucleus with multiple nuclear lobes each with a large inclusion like nucleolus about the size of a small lymphocyte

Front 41

reed-sternberg cells mononuclear variant

Back 41

single nucleaus with a large inclusions like nucleolus

Front 42

reed-sternberg cells - lacunar variant

Back 42

more delicate folded or multilobate nuclei and abundant pale cyto that is often disrupted, leaving the nucleus sitting in an empty hole

Front 43

reed-sternberg cells - lymphohistoocytic variant

Back 43

polypoid nuclei, inconspicuous nucleoli, and moderately abundant cytoplasm

Front 44

HL - lacunar variant, deposition of collagen bands in lymph nodes

Back 44

nodular sclerosis type

Front 45

HL - heterogenous cellular infliltrate, mononuclear variants, EBV in 70%

Back 45

mixed-cellularity

Front 46

HL - reactive lymphocytes, mononuclear variant and normal
ebv 40%

Back 46

lymphocyte rich

Front 47

HL - depletion of lymphocytes, 90% EBV

Back 47

lymphocyte depletion

Front 48

HL - popcorn cells, L&H variants that express CD20 and BCL6. ebv not present, males less than 35 with cervial lymph nodes

Back 48

lymphocyte predominance

Front 49

EBV activates what in HL?

Back 49

NF-kappaB

Front 50

60 year old man. asymptomatic or generalized lymphadenopathy and/or hepatosplenomegaly. smudge cells and proliferation centers

Back 50

CLL/SLL

Front 51

occurs in setting of T cell immuno (hiv). neoplastic B cells infected with EBV

Back 51

diffuse large b cell lymphoma

Front 52

malignant pleural or ascitic effusion. cells infected with HSHV/HHV-8

Back 52

diffuse large b cell lymphoma

Front 53

express high levels of cyclin D

Back 53

mantle zone lymphoma

Front 54

lymph node tumor cells surround reactive germinal centers to produce a nodular appearance

Back 54

mantle cell lymphoma

Front 55

MALToma is what type of lymphoma?

h pylori, sjogren, hashimoto. chronically induced

Back 55

marginal zone lymphoma

Front 56

presents as destructive mass as nasopharyngeal area, testis, skin. tumor cell inflitrate typically surrounds and invades small vessels, leading to ischemic necrosis

EBV

Back 56

extranodal NK/T-cell lymphoma

Front 57

how does mycosis fungoides/sezary attack skin?

Back 57

tumor cells express adhesion molecule CLA and the chemokine receptors CCR4 and CCR10

this homes the CD4+ cells there

Front 58

dry tap

spenlic red pulp heavily infiltrated, obliteration of white pulp and a beefy red gross appearance

Back 58

hairy cell leukemia

Front 59

esterase positive

Back 59

monoblasts

Front 60

oxidase positive

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myeloblasts

Front 61

immunoglobulin rearrangement seen in?

Back 61

CLL

HL

Front 62

cd15

Back 62

HL