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16 Cards in this Set
- Front
- Back
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List 2 TCAs.
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1. Amitryptyline (Elavil)
2. Imipramine (Tofranil) |
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moa of TCAs.
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inhibits presynaptic reuptake of NTs NE and S
ANTICHOLINERGIC action at the CNS and peripheral receptors |
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2 indications for TCAs.
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1. Depression
2. obstructive sleep apnea |
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8 side effects of TCAs.
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1. sedation
2. anticholinergic effects (dry mouth, blurred vision) 3. confusion (esp elderly) 4. photosensitivity 5. disturbed concentration 6. orthostatic hypotension 7. BM depression 8. urinary retention |
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How long does it take for a TCA to have a therapeutic response?
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1-3 wk
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How long does it take for a TCA to have a maximum response?
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6-9 wk
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When should a pt take a TCA? Why?
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daily at night to promote sleep and to decrease side effects during the day
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Any special precautions to take when a pt is on a TCA?
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yes- orthostatic hypotension precautions
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What should you tell the pt in regards to TCA side effect expectations?
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the side effects will decrease over time
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What should you give a pt who has dry mouth from a TCA?
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sugarless lozenges
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Should you abruptly stop taking a TCA?
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NO
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What are the potential consequences of abruptly stopping a TCA? (5)
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1. headache
2. vertigo 3. nightmares 4. malaise 5. weight change |
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What 3 drugs should be avoided in combination w/ TCAs?
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1. alcohol
2. sleep-inducing drugs 3. OTC drugs |
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What environmental factor should a pt on a TCA avoid?
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sun exposure - wear sunscreen while on TCAs
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What significant side effects are older adults more likely to experience when taking TCAs?
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1. anticholinergic side effects
2. sedation effects |
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What compound do TCAs increase in the brain?
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brain amine levels
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