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10 Cards in this Set
- Front
- Back
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Criteria for the Diagnosis of Autoimmune diseases?
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The presence of an autoimmune reaction
Evidence that such a reaction is not secondary to tissue damage, The absence of another well-defined cause of the disease. |
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Patterns of Autoimmune Disease?
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Organ specific
Non-Organ specific |
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what are Systemic or Non-Organ Specific Disorders?
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Systemic Lupus Erythematosus(SLE)
Rheumatoid arthritis Systemic Sclerosis (Scleroderma) Sjögren’ssyndrome Inflammatory Myopathies |
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Characteristics of Sjögren’sSyndrome?
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90% occur in females
Salivary glands are enlarged due to lymphocytic infiltrates Dry mouth Dry eyes 40x increased risk of developing Non-Hodgkin B-cell lymphoma |
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Immunodeficiency Diseases can be divided into..
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Primary and secondary
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AIDS -Core contains
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Major capsidprotein p24
– Nucleocapsidprotein – Two copies of genomic RNA – Three viral enzymes (protease, reverse transcriptase and integrase) |
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Name 6 organ specific autoimmune diseases
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Hashimoto thyroditis
Autoimmune haemolytic anaemia Multiple sclerosis Type 1 Diabetes Graves disease Ulcerative colitis |
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Three major routes of infection of AIDS?
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Sexual contact
Parenteral inoculation Mother to infant tx |
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Describe pathogenesis of AIDS
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HIV enters cells via gp120 glycoprotein - mainly cells with CD4 molecules
These are T-cells, Macrophages and Glial cells Viral replication leads to viremia which is controlled by immune response. It then enters latent phase. Gradual erosion of CD4+ cells. Ultimately very little CD4+ cells and patient develops clinical symptoms of AIDS. |
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Some clinical features of AIDS?
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lymphadenopathy, diarrhoea, night sweats, oral candida, weightloss
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