1/23/09 Diuretics Beavis Systems Utcom

Front 1

how can loop diuretics lead to hyperglycemia?

Back 1

loop diuretics can lead to hypokalemia, and as K stimulates insulin, this will lead to low insulin and hyperglycemia

Front 2

what are some side effects of loops, in addition to the serum chemistries?

Back 2

allergy and ototoxicity

Front 3

if someone is allergic to sulfas, and you need a Loop diuretic, what can you Rx?

Back 3

ethacrynic acid

Front 4

how can thiazide diuretics affect:
K
H+
Uric Acid
Sugar Levels
Calcium
[Na]
Cholesterol

Back 4

K and H+ : thiazides can lead to hypokalemic acidosis as more will be excreted in the CD as excess Na will be reabsorbed there
Uric Acid - more will be reabsorbed due to hypovolemia
-can lead to hyperglycemia
-can lead to hypercalcemia, as Ca competes with Na in DCT
-can lead to hyponatremia
-can lead to high LDL and low HDL

Front 5

what drug might promote Ca2+ reabsorption for kidney stones?

Back 5

thiazide diuretics, as Ca competes with Na in the DCT

Front 6

what is the first line drug for HTN regarding diuretics?

Back 6

thiazides

Front 7

what diuretic is first indicated in treating pulmonary/peripheral edema and ascites?

Back 7

Loops (for ascites it is used secondarily with spironolactone)

Front 8

Spironolactone - effects on plasma:
main uses:

Back 8

plasma: leads to hypokalemia, acidosis
main use: to correct K and H+ imbalance from Loop and Thiazide diuretics, or if excess [Aldo]. also for severe HF to slow remodeling

Front 9

osmotic diuretics like Mannitol can alleviate ____ edema yet they can also lead to ____ edema. other uses?

Back 9

can help w/ cerebral edema but can lead to pulmonary edema
- can also be used for acute closed-angle glaucoma; maintain perfusion of kidney in times of acute kidney failure

Front 10

options to treat SIADH?

Back 10

Lithium, or Demeclocycline - both are "ADH antagonists" thus lead to diabetes insipidus

Front 11

most important diuretic for ascites:

Back 11

spironolactone