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29 Cards in this Set
- Front
- Back
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There are ? phases of new drug administration before it can be used within the public.
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four
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In phase ? , the drug is tested on healthy volunteers to make sure the drug can be given safely to people.
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one
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Phase ? involves trials with human subjects who have the disease for which the drug is thought to be effective.
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two
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In phase ? large numbers of patients in medical research centers receive the drug. This larger sampling provides information about ? or ? adverse affects.
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three
infrequent rare |
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The ? approves a new drug application if phase three studies are satisfactory.
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FDA
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Phase ? is voluntary and involves post-market surveillance of the drug's therapeutic effects.
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four
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Name 10 administration routes for medications.
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Mouth- Buccal, sublingual, translingual
Gastric Intradermal Intramuscular Intravenous Oral Rectal/Vaginal Respiratory SubQ Topical Special(epidural, intrapleural, intraperitoneal, intraarticular) |
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The safest, most convenient, least expensive way for a patient to receive meds is ?
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Orally
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If we are administrating meds orally the pt. must be ? and able to ?
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conscious
swallow |
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? is the movement of drugs in the body.
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Pharmacokinetics
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Name the four ways that drugs move throughout the body?
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MADE=
Metabolism Absorption Distribution Excretion |
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Absorption of drugs can be ? or ?.
? % of absorption takes place in the ? |
passive
active 80 small intestine |
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Passive absorption take place from ? to ? concentrations
Active absorption takes place from ? to ? |
high to low
low to high |
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? absorption is the way the body processes drugs the most.
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active
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The four ways that Meds are absorbed in 1-3 minutes are ?,?,?,?
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IV, Inhaled, Intra-arterial, Intra-thecal
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Nomogram for absorption is ISR SPIT.
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I=Inra-arterial, Intraveneous, Inhaled, Intra-thecal 1-3 minutes
S=Sublingual 3-5 minutes R= Rectal 15-30 minutes S=SubQ 30-45min P=PO 30-45min I= IM 30-45min Topical= 45-60 min |
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give nitro x3 , five minutes apart so nitro acts in ? minutes. Each pill acts in 3 to 5 minutes so we should see some results in 15 minutes max.
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15
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the 2nd factor that effects absorption is how the drugs are ? e.g. liquids, suspension, powder, capsules, tablets coated tablets, enteric coated
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formed/prepared
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The first way that drug absorption is affected is the ? of administration
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Administration route
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The 3rd factor affecting absorption is ?
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intestinal interference
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The 4th factor affecting absorption is ? metabolism.
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liver metabolism
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When drugs first pass through the liver an enzyme ? breaks down drugs and gets them ready for absorption into the ?
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P450
blood |
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The first pass of drugs through the liver is called ?
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bio-transformation
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Absorption factor #5 for drugs is ?
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blood flow
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Absorption factor #7 for drugs is ?
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Pain/Stress
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Which muscles have the best ability to absorb drugs?
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deltoids
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The 7th factor for drug absorption is ?
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pain/stress
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The 8th factor for drug absorption is ?
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Drug combinations
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What are the 8 factors affecting drug absorption?
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ADILBDPD
A(administration route) DIL(Drug form, Intestinal interference, Liver Metabolism) B=Butt (blood flow) D=Does(Diet) P=Painful(pain/stress) D=Damage(drug combination) |
