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10 Cards in this Set
- Front
- Back
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What is a microtubule composed of?
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Helical array of polymerized dimers of alpha and beta tubulin
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Where are microtubules found?
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Flagella, cilia, mitotic spindles
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What are molecular motor proteins?
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Transport cellular cargo toward opposite ends of microtubule tracks
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What does Dynein do?
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Transport retrograde to microtubule
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What does Kinesin do?
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Anterograde to microtubule
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What is Chediak-Higashi syndrome?
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mutation in lysosomal trafficking regulator gene LYST
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What are the symptoms of Chediak-Higashi syndrome?
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Recurent pyogenic infections, partial albinism, peripheral neuropathy
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What is the structure of cilia?
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9 + 2 arrangement of microtubules
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What is Kartagener's Syndrome?
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Primary ciliary dyskinesia
Immotile cilia due to a dynein arm defect |
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What is the result of Kartagener's Syndrome?
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Male infertility (immotile sperm)
Female infertility Bronchiectasis and recurrent sinusitis, situs inversus |
