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15 Cards in this Set
- Front
- Back
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What is the cell cycle process regulated by?
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Cyclins, CDK's, tumor suppressors
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What is the shortest phase of cell cycle?
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Mitosis
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What are CDK's?
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Cyclin-dependent kinases, always there, constitutive and inactive
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What are cyclins?
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Regulatory proteins that control cell cycle events, activate CDK's
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What is the cyclin-CDK complex?
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Must be activated and inactivated for cell cycle to progress
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What are the 2 tumor suppressors?
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p53 and hypophosphorylated Rb, which inhibit G1--> S progression
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What are the actions of permanent cells?
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Remain in G0, regenerate from stem cells
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What are some examples of permanent cells?
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Neurons, skeletal and cardiac mm, RBC's
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What are the actions of stable cells?
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Enter G1 from G0 when stimulated
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What are some examples of stable cells?
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Hepatocytes, lymphocytes
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What are the actions of labile cells?
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Never go to G0, divide rapidly with a short G1
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What are some examples of labile cells?
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Bone marrow, gut epithelium, skin, hair follicles, germ cells
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How is the cell cycle stopped?
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When cyclins are degraded by ubiquitin protein ligase
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What are the 2 instigators of G1--> S?
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Cyclin D --> binds to CDK4, phosphorylation of Rb protein
Cyclin E --> binds to CDK2 |
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What are the 2 instigators of G2 --> M?
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Cyclin A --> binds to CDK2
Cyclin B --> binds to CDK1 complex |
