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14 Cards in this Set
- Front
- Back
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What is the starting product of the Arachidonic pathway?
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Membrane lipid
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What converts membrane lipids into Arachidonic acid?
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Phospholipase A2
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What do corticosteroids inhibit?
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The conversion from membrane lipids to arachidonic acid and the COX 1 & 2 pathways
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What are the 2 pathways that arachidonic acid can be converted into?
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Hydroperoxides by lipoxygenase
Endoperoxides by cycloxygenase |
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What is lipoxygenase converted into?
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Leukotrienes
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What agent blocks the conversion to leukotrienes?
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Zileuton
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What do leukotrienes do?
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Neutrophil chemotaxis
Increased bronchial tone |
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Which 2 agents block leukotrienes action on bronchial tone?
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Zafirlukast, montelukast
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What do zafirlukast and montelukast treat?
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Asthma, allergies
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What 3 things are endoperoxides converted into?
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Prostacyclin
Prostaglandin Thromboxane |
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What 4 things inhibit the conversion from Arachidonic acid to Endoperoxides?
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NSAIDS, aspirin, acetaminophen, COX-2 inhibitors
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What do prostacyclins do?
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Decrease:
Platelet aggregation Vascular tone Bronchial tone Uterine tone |
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What do Prostaglandin's do?
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Increase:
Uterine tone Bronchial tone Decrease vascular tone |
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What do thromboxanes do?
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Increase:
Platelet aggregation Vascular Tone Bronchial Tone |
