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24 Cards in this Set
- Front
- Back
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What is chronic pancreatitis?
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Progressive, irreversible destruction of the pancreas by repeated bouts of mild pancreatitis
-alchohol or biliary tract disease |
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What is chronic calcifying pancreatitis?
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Most common type resulting from alcoholism
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What is obstructive pancreatitis?
Caused by? |
Less common, nonlobular destruction
Caused by stenosis of sphincter of Oddi from cholithiasis or pancreatic carcinoma |
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Chronic pancreatitis sonographically
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Mixed echo texture hyperechoic-fibrosis
hypoechoic-inflammation |
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Chronic pancreatitis
findings |
Focal mass lesion-calcifications
Pancreatic duct dilation 5-10% Pseudocyst formation |
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Adenocarcinoma
Definition |
Pancreatic cancer
4th common death by cancer Majority from ductal epithelium |
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Adenocarcinoma
Incidence |
Rare before 40
2/3 over 60 2-3 month survival rate 1 year survival rate is 8% |
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Adenocarcinoma
Clinical symptoms HEAD |
70% this location
Earlier than in tail Assoc. with bile duct obstruction Courvoisiers Sign (25%) |
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Adenocarcinoma
Clinical symptoms BODY & TAIL |
15-20% body
5% tail Weight loss, pain, jaundice, vomiting, diabetes, malabsorption |
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Adenocarcinoma
sonographically |
Poorly defined mass
Uncinate process mass-more round appearance Necrosis-cystic area w/in the mass |
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Adenocarcinoma
indirect signs |
Dilation of pancreatic duct (over 2-3cm)-more in head
Mass may or may not be present |
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Adenocarcinoma
Double duct sign |
Mass will extend inside and dilate the CBD and pancreatic duct
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Cystic Neoplasms
percents |
10-15% pancreatic cysts
1% pancreatic cancers |
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Cystic Neoplasms
Microcystic |
Serous (fluid filled)
Benign-no surgery Diffuse Very small-2cm Solid looking Caclified scar in 20% |
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Cystic Neoplasms
Macrocystic |
Mucous filled
Malignant-surgery recomm. Over 2cm Solid, clear, clear w/ debris |
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Islet Cell Tumors
Occur from and with.... |
Arise from multipotential stem cells, slow growing
Called APUD in ductal epithelium Can be part of MEN syndrome |
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MEN syndrome
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multiple tumors secrete different polypeptides
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Islet Cell Tumors
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Diffuse
Malignancy can't be dx microscopically -Electron microscopy -Immunoassay tech Necrosis, hemorrhage, calcification (large malignant types) |
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B Cell Tumors
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Insulinomas-most common
Usually benign Ages 40-60 Hypoglycemic symptoms Body or tail Well encapsulated 70% solitary adenomas |
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G Cell Tumors
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Gastrinomas
Malignant Zollinger-ellison syndrome Second most common Ages 40-60 Diarrhea, peptic ulcer 85-90% in head 75% diffuse |
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Rare Islet Cell Tumors
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Malignant-glucoagonmas, vipomas
Benign-somatostatinomas |
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Non-Islet Cell Tumors
Occur with.... |
(rare)
giant cell tumors adenosquamous, mucinous, anaplastic, acinar cell carcinomas connective tissue tumors mets lympomas |
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Non-Islet Cell Tumors
Definition and incidence |
Solid and papillary tumors-young women, large well defined thich walled cystic lesions (from hemorrhage or necrosis)
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Non-Islet Cell Tumors
Non-Hodginks Lympomas |
Involve extra lymph node organs
Solitary or Diffuse |
