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25 Cards in this Set
- Front
- Back
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functional inactivation of a lymphocyte
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anergy
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B cells that can't enter the spleen or lymph nodes because they have not been activated by both antigen and T cell interaction and die by apoptosis
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anergic B cells
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costimulatory signal required by a B cell to avoid being anergized
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CD40L (T) with CD40 (B)
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costimulatory signal required by a T cell to avoid being anergized
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B7 (APC) with CD28 (T)
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cytokine expressed by suppresor T cells
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IL-2
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eye, testis, brain, ovary, placenta
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immune priveleged sites
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an autoimmune disorder in which autoantibody acts as an antagonist to Ach receptrors leading to severe muscle weakness and ultimate respiratory failure
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myasthenia gravis
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an autoimmune disorder in which TSH receptor receives continual stimulation due to an autoantibody
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Graves disease
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an autoimmune disorder in which autoantibodies are produced against dsDNA and other nuclear components (ANA antibodies)
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systemic lupus erythematosus
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disease which is know as red wolf because of a butterfly rash
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systemic lupus erythematosus
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thyroid disease that is a result of antibodies agains two major thyroid proteins (thyroid peroxidase and thyroglobulin)
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Hasimoto's thyroiditis
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autoimmune disorder that results in demyelination of CNS nerve axons (can be relapsing-remitting or chronic progressive)
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multiple sclerosis
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autoimmune disorder in which insulin producing β cells of the islets of Langerhans are attacked by cytotoxic CD8 cells
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type I diabetes mellitus
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IgE mediated reactions (allergy), immediate hypersensitivity
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type I hypersensitivity
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cytolytic or cytotoxic reaction where IgM or IgG bind inappropriately to antigen on self-cells
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type II hypersensitivity
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immune complex reactions that occur due to accumlation of Ig or IgG complexes
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type III hypersensitivity
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cell mediated hypersensitivity (T cell mediated) that is typically delayed
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type IV hypersensitivity
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have receptors that bind to Fc region of IgE in a Type I hypersensitivity reaction and then cross-link antigen
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mast cells and basophils
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rhinitis, dermatitis, food allergies, obstructive pulmonary diseases, systemic reactions (like anaphylaxis)
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manifestations of Type I hypersensitivity
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type of hypersensitivity that result illustrated by a transfusion reaction
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Type II
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1. Cell lysis via activation of complement through IgM or IgG 2. Phagocytosis through engagement of IgG Fc portion on phagocytic cells 3. Autoantibodies acting as antagonists or agonists on receptors
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3 Modes of Type II Hypersensitivity Reaction
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complement components released during a type III hypersensitivity reaction that result in an acute inflammatory response
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C3a and C5a
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cells, which along with Th1 cells, get activated in a type IV hypersensitivity reaction and release pro-inflammatory cytokines
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Th17 Cells
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poison ivy (contact dermatitis), PPD test, granulomatous hypersensitivity
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Type IV Hypersensitivity examples
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type I diabetes mellitus, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, chronic infections, contact sensitivity, viral hepatitis, superantigen mediated diseases
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Type IV Hypersensitivy diseases
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