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6 Cards in this Set
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TB tx
what is rifamate rifater |
Isoniazide 300mg daily x 6 months
rifampin 600 mg daily x 6 months pyrazinamide 15-30 mg/kg/day x 2 months Rifamate (INH/RIF) 150/300mg Rifater (INH/RIF/PYRAZINAMIDE) 50/120/300) pyrazinamide may precipitate gouth pyrazinamide is converted to pyrazinoic acid in susceptible strains of mycobacterium which lowers the pH of the environment |
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Isoniazid
treatment for tox BBW Liver Enzyme effect |
Nydrazid - 100mg/mL IM inj.
treatment for INH tox pyridoxine BBW hepatitis severe and sometimes fatal LFTs!!! liver enzyme inhibitor inreases phenytoin and diazepam give 1 hr before AL hydroxide gel |
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rifampin
MOA monitor LE effects |
MOA
broad spectrum antibiotic monitor LFTs!! - can be hepatotoxic potent liver enzyme inhibitor |
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ethambutol
Use ADR effect on uric acid |
Myambutol
used in combination; never alone, to prevent the development of resistant strains ADR - can decrease visual acuity - get eye exam before and after treatment - normally reversible will decrease secreation of uric acid and may potentiate gout |
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what is the TB skin test sometimes called?
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PPD Tuberculin test
or Mantoux skin test PPD - purified protein derivatives |
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Other TB drugs
Rifabutin PASA Capreomycin Cycloserine |
Rifabutin - mycobutin - related to rifabutin
PASA - paraaminosalicylic acid Capreomycin - Capastat Cycleserine - Seromycin |