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44 Cards in this Set

  • Front
  • Back
Eicosanoids are a diverse group of molecules mainly derived from?
arachidonic acid
arachidonic acid is produced from?
membrane phospholipids
arachidonic acid is produced by the action of?
phospholipase A2
eicosanoids termed?
autocrine regulators (local hormones)
eicosanoids include?
1) prostaglandins
2) thromboxanes
3) leukotrienes
eicosanoids regulate?
1) inflammation
2) pain reception
3) blood flow
4) smooth muscle contraction
eicosanoids are produced in?
very small amounts, and have short half-lives
prostaglandins are?
1) arachidonic acid derivatives
2) contain a cyclopentane ring
action of prostaglandins?
1) inflammation
2) reproductive processes
3) digestion
thromboxanes contain?
a cyclic ether group
leukotrienes are?
noncyclic (linear)
leukotrienes are known to be components of?
SRS-A (slow releasing substance of anaphylaxis)
1) vosodilation (low [ })
2) vosoconstriction (high [ ])
3) bronchial muscle contraction
4) renin secretion
5) inhibit plt aggregation
PG-D2 causes only vasoconstriction in the?
pulmonary circulation
1) potent vasodilation
2) < BP
3) > blood flow to heart and kidney
4) inhibit B-lymp proliferation & differentiation to plasma cells
5) inhibit IL-1 & T cell proliferation
1) relax bronchial muscle
2) contracts uterine and intestinal smooth muscle
3) > body temp
4) hyperalgesia
5) inhibit gastric secretion
6) > GI mucus secretion
1) constrict pulm vessels
2) contracts bronchial muscle
3) contract uterine & GI muscles
PG-I2 (prostacyclin)
1) inhibit plt aggregation
2) cause hypotension
3) vasodilation
4) relax uterine tone
5) cytoprotectant
1) plt aggregation
2) vasoconstriction
3) bronchoconstriction
TX-A2 is produced by?
1) leukocyte chemotaxis
2) hyperalgesia
3) stimulate Bcell proliferation
LT-C4 & LT-D4
1) bronchoconstrictors
2) > microvascular permeability, plasma exudation, mucus secretion
function as NTM
1) stimulates migration of aortic smooth muscle cells
2) chemotactic factor
prostaglandins in OB
1) 1st & 2nd trimester abortion
2) Carboprost (IM)
3) Dinoprostone (intravag)
4) induction of labor
5) control postpertum uterine atony and hemorrhage
PTG in pediatrics
1) maintain patency of ductus arteriosus
2) Alprostadil (IV gtt)
PTG in impotence
vasodilation with penile injection (Alprostadil)
cytoprotection of the stomach in pts with on NSAIDS
PG-I2 used to prevent plt aggregation in?
dialysis machines
Misoprostol (Cytotec)
1) synth. oral PG-E1 analog
2) prevent ulcers
SE of Misoprostol
1) transient diarrhea
2) C/I in pregnant pts
Dinoprostone (Cervidil, Prostin E2 suppository, Prepidil gel)
1) synth. PG-E2 analog
2) terminate pregnancy
3) facilitate labor
SE of Dinoprostone
1) vomiting
2) diarrhea
3) transient fever
Carboprost tromethamine (Hemabate)
1) synth. derevatives 15-methyl-PG-F2alpha
2) induce abortion
3) control postpartum hemorrhage
SE of Hemabate
1) N/V
2) diarrhea
3) transient pyrexia
4) hypotension with large dose
Alprostadil (Prostin VR pediatric)
1) naturally occuring form of PG-E1
2) maintain a patent ductus arteriosus
SE of Alprostadil
1) apnea (10-12%)
2) fever, flushing, hypotension, bradycardia, Sz, diarrhea, cardiac arrest
Alprostadil penile injection (Caverject)
1) naturally occuring form of PG-E1
2) for impotence
Sildenafil (Viagra)
1) not a PG preparation
2) increase blood flow in the corpus cavenorsum
Viagra is contraindicated with?
organic nitrate vasodilators
(ex) Nitrous = < BP
Epoprostenol (Folan, Cycloprostin)
1) PG-F analog
2) prevent plt aggregation in dialysis machine
3) for pulmonary HTN
Latanaprost (Xalatan)
1) analog of PG-F2 alpha
2) eye drop, for > IOP
Montelukast (Singulair)
1) leukotriene blocker
2) antiasthmatic
3) Zamfirlukast (Accolate)
Zileuton (ZyFlo)
1) inhibitor of 5-lipoxygenase
2) for asthma