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8 Cards in this Set
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Tacrine
MOA Indication Dose Monitoring Side effects |
MOA: AChI
Indication: mild to moderate Alzheimer's Dose: 10mg x 16 wks, then check ALT; if it is not 3x ULN then one can start to increase dose. Monitoring: AST and bilirubin Side Effects: N/V and **LIVER DAMAGE** |
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Exelon (Rivastigmine)
MOA Indication Dose Monitoring Side effects Switching from PO to patch |
MOA: AChEI
Indication: Mild to moderate dementia in Alzheimer's and Parkinsons Dose: Alzheimer's: 1.5 mg BID and increase dose at minimum 2 weeks Parkinson's: 1.5 mg BID and increase dose at minimum 4 wks **MAX IS 6 mg BID Monitoring: Weight, rivastigmine can cause weight loss (PATCH) Side effects: GI, N/V, weight loss Switching from PO to patch po dose ,6 mg daily = 4.6mg pacth po dose, 6-12 mg daily - 9.5 mg patch |
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Razadyne (Galantamine)
MOA Indication Dose Side effects |
MOA: AChEI
Indication: Alzheimers Dose: start 8 mg and after 4 weeks can increase 8 mg up to 24 mg Side effects: N/V, loss of appetite, increase bowel movements |
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Aricept (Donepezil)
MOA Indication Dose Side effects Over dose treatment |
MOA: AChEI
Indication Alzheimer's Dose: Mild to Moderate 5-10mg q hs Moderate to Severe 10-23 mg hs Side effects: N/V, diarrhea, muscle cramp, fatigue, loss of appetite; weight loss most significant with 23 mg dosing Antidote: Tertiary anticholinergics such as atropine: 1 - 2 mg IV and titrate up |
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Namenda (memantine)
MOA Indication Dose Side effects |
MOA: NMDA receptor antagonist; protects the post synaptic receptor from getting too much glutamate; glutamate is over produced in pts with dementia...this improves patients ADLs
Dose: 5mg q d and weakly increases up to 10 mg BID Side effects: HA, constipation, confusion, dizziness Synergistic with AChEI; often used in conjunction w/ Aricept (donepezil) |
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What do AChEIs do?
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Improve cognitive performance
"Oh, I remember today is Friday." |
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What do NMDA receptor antagonists do?
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Improve patients activities of daily living (ADLs)
"Look, I can hold my fork." |
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Alzheimer's risk factors?
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Age > 65
Fam Hx Female Mild Cognitive Impairment Lifestyle: HTN, hypercholesteremia, DM, sedentary lifestyle |
