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13 Cards in this Set
- Front
- Back
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5 major classes of steroids
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Adrenal:
- Mineralocorticoid - Glucocorticoid Male Gonadal: - Androgen Female Gonadal: - Progestins - Estrogens |
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Mineralocorticoid:
- # of carbons - Major site of synth - example |
C21
Adrenal Cortex: Glomerulosa cells Aldosterone |
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Glucocorticoid
- # of carbons - Major site of synth - example |
C21
Adrenal Cortex: Fasciculata cells Cortisol |
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Androgen
- # of carbons - Major site of synth - example |
Major:
-C19 -Testis: Leydig cells -Testosterone Minor: -Adrenal Cortex: Reticularis cells -DHEA |
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Progestins
- # of carbons - Major site of synth - example |
C21
Corpus luteum: Stromal cells Progesterone |
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Estrogens
- # of carbons - Major site of synth - example |
C18
Ovary Follicle: Theca and Granulosa cells Estradiol |
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Endocrine Tissues
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Pineal
Hypothalamus Pituitary thymus pancreas ovary testes Kidney adrenal parathyroid thyroid |
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hypothalamic-pituitary axis
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makes the regulatory hormones that control the making of all steroid hormones (except Mineralocorticoid)
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renin-angiotensin system
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makes the regulatory hormones that control the making of Mineralocorticoid hormones
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pathway to make cortisol
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- stress causes production of monoamines
- monoamines causes release of corticotrophin releasing hormones (CRH) in hypothalmus - CRH transported to anterior pituitary and binds to receptors on corticotrophs - corticotrophs transcribes POMA - POMA turns into ACTH, which goes into circulatory sys - ACTH bind to receptors of fasciculata - fasciculata promotes conversion of cholesterol into cortisol |
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pathway to stop making cortisol
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- high cortisol inhibits CRH producation and secretion
- crotisol binding to receptor inhibits ACTH production |
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what activates and what inhibits renin production
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activates:
- less fluid volume - less Na+ concentration inhibits: - aldosterone (end product of renin pathway and functions to increase fluid volume and Na+ concentration) |
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Renin makes...
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- Renin cuts off section from N-terminus of a2-globulin make angiotensin
- Angiotensin converting enzyme (ACE) cuts off section from C-terminus of angiotension I to make angiotensin II - amino peptidase quickly converts Angiotensin II angiotensin III |
