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12 Cards in this Set
- Front
- Back
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Atropine sulphate
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Use w/ other anticholinergics may increase vagal blockade. Possible adverse effects when used with digitalis, cholinergics, or neostigmine.
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Sodium bicarb
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Vasopressors may be deactivated.
May precipitate in calcium solutions. Alkalinization of urine may shorten half lives of certain drugs. |
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Epinephrine
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May be deactivated by alkaline solutions (sod bicarb, furosemide).
MAO inhibitors may potentiate the effects of epi. Beta-adrenergic antagonists may blunt inotropic response. Sympathomimetics and phosphodiesterase inhibitors may exacerbate dysrhythmia response. |
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Dopamine
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May be deactivated by alkaline solutions (sod bicarb and furosemide).
MAO inhibitors may potentiate the effects. Sympathomimetics and phosphodiesterase inhibitors exacerbate dysrhythmia response. Beta adrenergic antagonists may blunt intotropic response. When administered w/ phenytoin, hypotension,bradycardia, and seizures may develop. |
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Licocaine
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Metabolic clearance of lidocaine my be decreased in pts taking beta adrenergic blockers or in pts w/ decreased cardiac output or liver dysfunction.
Apnea induced w/ succinylcholine may be prolonged w/ large doses of lidocaine. Cardiac depression may occur if lidocaine is given concomitantly w/ IV Phenytoin. Additive neurological effects may occur w/ procainamide and tocainide. |
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Amiodarone
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May pontentiate bradycardia and hypotension w/ beta blocker and calcium channel blockers.
May increase risk of atrioventricular block and hypotension w/ calcium channel blockers. May increase anticoagulant effects of warfarin. May decrease metabolism of phenytion, procainamide, quinidine, and theophylines. Y site incompatibilities w/ furosemide, heparin, and sod bicarb. Routine use in combination w/ drugs that prolong Q-T interval is not recommended. |
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Morphine
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CNS depressants may potentiate effects (respiratory depression, hypotension, sedation)
MAO inhibitors may cause paradoxical excitation Phenothiazines may potentiate analgesia |
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Fentanyl
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Effects may be increased when given w/ other CNS depressants or skeletal muscle relaxants.
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Adenosine
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Methylxanthines (caffeine and theophylline) antagonize the action of adenosine
Dipyridamole potentiates the effect (reduction of dose may be required) Carbamazepine may potentiate the AV nodal blocking effect |
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Aspirin
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Decreased effects w/ antacids and steroids
Increased effects w/ anticoagulants, insulin, oral hypoglycemics, fibrinolytic agents |
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Nitroglycerin
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Other vasodilators may have additive hypotensive effects
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Oxygen
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None significant
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