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6 Cards in this Set
- Front
- Back
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What are the ingredients used for de novo nucleotide synthesis?
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amino acids, ATP, folates, carbon dioxide.
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Which three amino acids supply nitrogen for PURINE nucleotide synthesis? Where do carbons come from?
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glycine, aspartate, glutamine.
glycine, FH4, bicarbonate. |
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Parent purine nucleotide (inosine monophosphate) is converted to what?
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IMP --> GMP, AMP
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Major inhibitors of purine nucleotide synthesis?
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5-FU (thymidylate synthase)
allopurinol (xanthine oxidase inhibitor) MTX (dihydrofolate reductase) acyclovir/gancyclovir/azothymidine (AZT) (chain terminators) AMP, GMP, IMP |
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What two enzymes are involved in the salvage pathway for purine biosynthesis?
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APRT (adenine phophoribosyl transferase); HGPRT (hypoxanthine-guanine phosphoribosyl transferase)
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Deficiency of HGPRT results in what disease?
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Lesch-Nyhan syndrome - cannot salvage guanine successfully. Self mutilation and overproduction of uric acid.
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