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12 Cards in this Set
- Front
- Back
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trypsinogen --> trypsin?
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enteropeptidase
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What autocatalytic properties does trypsin have?
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Activates chymotrypsin, proelastase, procarboxypeptidases A & B
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Problem in Hartnup's disease?
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inability to transport neutral amino acids, can lead to niacin deficiency which then leads to pellagra. get niacin deficiency becausee tryptophan is a precursor for niacin.
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Which populations can absorb undigested, whole proteins?
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Babies, older adults. Can cause urticaria.
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What does gastrin stimulate?
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Secretion of HCl and pepsinogen
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What does secretin stimulate?
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Flow of pancreatic juice and bile. Secretin = basic polypeptide
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Cholecytokinin stimulates what two actions?
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1) Open Sphincter of Oddi (i.e. bile)
2) Stimulate pancreatic acinar cells to produce enzymes |
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What activates pepsinogen?
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acid pH of stomach
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What are endopeptidase reactions?
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Pepsin, trypsin, chymotrypsin, elastase activations
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What are the exopepsidase reactions?
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carboxypeptidase activation (A and B); prolidase, aminopeptidase
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ATP-dependent proteolysis uses what system? Which enzyme is needed?
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Proteasome-ubiquitin system. Ubiquitin protein ligase is required (E1/E2/E3)
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ATP-independent proteolysis uses which enzymes? Where does it occur? For what kinds of proteins is this pathway good for?
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cathepsins (proteases) located in the lysosomes of liver cells. Good for extracellular, membrane associated proteins; also insoluble proteins (taken up by pinocytosis). FYI other systems are calpains/caspases
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