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4 Cards in this Set

  • Front
  • Back
eicosanoids are derived from what? how is it released?
arachidonic acid. histamine stimulate a2 or phospholipase c to release esterified arachidonic acid from plasma membrane
what is dietary precursor for arachidonic acid?
linoleate - c 9, 12.
there are 3 pathways for arachidonic acid metabolism. name them.
1. cyclo-oxygenase - prostaglandin and thromboxane synthesis
2. lipoxygenase - leukotrienes, hetes, lipoxins
3. cytochrome p450 - epoxides, hetes, dihetees
Chronic NSAID use causes?
cut out cycloxygenase pathway (aspirin) and over production of lipoxygenase.