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14 Cards in this Set
- Front
- Back
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Linolate dbs? Linoleate db's?
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9, 12.
9, 12, 15. |
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Malate ---> Pyruvate produces what molecule?
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NADPH
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Fatty acid biosynthesis occurs in what compartment?
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CYTOSOL!
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What initiates FA synthesis?
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Citrate
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Two enzymes for FA synthesis.
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acyl-coA carboxylase, FA synthase
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What does acyl coA carboxylase do?
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condenses co2 (carried by biotin) to acetyl coa, to form malonyl CoA. This is the regulated step of FA biosynthesis.
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What does fatty acid synthase do?
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condenses acetyl CoA to malonyl coA, then adds 6 more malonyl CoA enzymes to form palmitate.
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Malonyl CoA is used for what pathways?
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MCoA is dedicated to fatty acid biosynthesis. Just one.
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Name the regulators of ACC acetyl coa carboxylase
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+ citrate
+ insulin (dephosphorylates ACC) - malonyl coA - palmitoyl coA - glucagon, epinephrine (fasting state - dont' want to make more FA's) - AMPK (from myosin ATPase) - PKA |
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FA synthase dimer - describe structure
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ACP carrier plus 7 catayltic centers. Growing FA chain gets shuffled from one end to other.
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Where does modification of fatty acid occur?
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ER
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Where are fatty acids desaturated?
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Smooth ER
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What does palmitate turn into?
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palmitoleate C16:1(9)
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What does stearate turn into?
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oleate (C18): 1(9)
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