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11 Cards in this Set
- Front
- Back
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how do you test for condyloma acuminata grossly?
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apply 3% acetic acid and look for white (from keratin and edema)
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what organism causes herpes genitalis?
what does it look like histologically? how does it present clinically? |
herpes simplex hominis (usually type II, sometimes type I)
histo: intranuclear inclusions, multinucleated cells w/ ground glass look clinical: vulvitis and edema, ulcerations of ectocervix, fever, inability to void, recurrent episodes w/ first the worst |
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what does a syphlitic chancre look like histologically? condyloma lata?
what does a chancre look like grossly? what does condyloma lata look like grossly? how do you test for syphilis? |
perivascular arteritis, plasma cells, spirochetes. condyloma latas same but w/ epithelial hyperplasia
chancre = ulcer, condyloma lata = warty dark field biopsy or immunofluorescence |
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What category are primary vaginal neoplasms usually in kids?
What category are primary vaginal neoplasms usually in adults? Name 2 major vaginal neoplasms in kids. |
Kids = sarcomas
Adults = epithelial Major kid neoplasms: sarcoma botyroides (striated - base of bladder or vagina) and leiomyosarcoma (smooth) |
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what organism causes vaginal intraepithelial neoplasia (VaIN)?
what is VaIN associated with or precursor of? how can you identify VaIN grossly? |
HPV 16 or 18
Cervical neoplasia or vaginal SCC gross: punctation pattern w/ 3% acetic acid |
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what does lichen sclerosis look like grossly (early)? grossly (late)?
what does it look like histologically? does lichen sclerosis lead to any cancer risks? |
early gross: butterfly lesion, white skin
late gross: labia minora shrinkage, perianal stenosis (kids), vagina stenosis histo: epithelial thinning, edema and fibrosis, chronic inflammatory infiltrate slight risk of SCC |
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name 3 precursors of VULVAR squamous cell carcinoma
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1) VIN2/3
2) differentiated VIN (lichen sclerosis) 3) chronic granulomatous vulvar dz / chronic inflammation |
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with what virus is vulvar intraepithelial neoplasia (VIN) associated with?
what can VIN be associated with or be the precursor to? what colors can VIN present as? how about distribution? which of those combinations is the most common? name and describe the 3 histopathologic types of VIN which of those types is NOT associated w/ HPV? |
HPV 16 and 18
cervical neoplasia, vaginal neoplasia, vulvar SCC white, red, pigmented; multifocal, unifocal, or confluent (white multifocal is most common) warty: lots of koilocytes and keratin basaloid: small, uniform, lack maturation differentiation: sclerosis and edema differentiated VIN associated w/ lichen sclerosis, not HPV |
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how does SCC from VIN look grossly? histologically?
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gross: red, eroded edges, invasive
histo: large nuclei, prominent nucleoli, pink cytoplasm |
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name 3 types of nonsquamous intraepithelial vulvar neoplasias
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paget's dz, melanoma in situ, invasive melanoma
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name the cutaneous subcategories of paget's dz
name the non-cutaneous subcategories of paget's dz how can cutaneous paget's dz look grossly? histologically? how do you identify paget's dz via IHC? what else does paget's dz resemble? |
cutaneous: primary intraepithelial neoplasm, invasive intraepithelial neoplasm, manifestation of cutaneous adenocarcinoma
non-cutaneous: manifestation of non-cutaneous adenocarcinoma, urothelial origin gross: inflammatory condition or white, excoriated, leaking lesion histo: keratinocyte like, but LARGER, prominent nucleoli, lots of cytoplasm IHC: contains CEA (carcinoembryonic antigen) looks like some forms of melanoma in situ |
