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11 Cards in this Set
- Front
- Back
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What family of viruses does VSV and Rabies (Lyssavirus) belong to?
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Rhabdovirus
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What is the signature structural components of Rhabdovirus?
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bullet shaped
negative ssRNA helical capsid lipid envelope peplomers are attachment proteins |
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What is the vector and transmission problems for rabies?
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any warm blood animal and can be transmitted through a bite (saliva through broken skin or mucus membranes) or a scratch
skunks, raccoons, and bats are the main US infected vector rodents are usually not involved |
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How are domesticated animals protected against rabies?
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they are vaccinated
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What is the pathogenesis of rabies?
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1. primary infection in muscle
2. viremia takes place over the course of about 2 weeks accompanied by prodrome 3. CNS signs occur during a time frame based on distance from bite site to brain 4. lots of virus replication takes place in the salivary glands after CNS exposure |
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What system is heavily infected and causes aggressive behavior?
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limbic system
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What is a histologically pathognomonic in brain tissue for rabies infection?
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Negri bodies
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What are the two main forms of rabies?
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1. furious - wide range of CNS symptoms, horrific hydrophobia
2. dumb - flaccid paralysis (not as common as furious) |
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What is the best tool for dx?
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epidemiology - immunofluorescence, RT-PCR, examination of animal brain tissue
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What is the tx?
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PROMPT post-exposure prophylaxis
thoroughly wash the wound with a lipid popping detergent, flush wound, with Ab passive immunization HRIG at wound site, HRIG injection in buttocks, active immunization IM deltoid for 0, 3, 7, 14, and 28 days |
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What should high risk groups of people do to prevent inoculation?
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pre-exposure prophylaxis with 4 days of IM injections
booster after exposure |
