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15 Cards in this Set
- Front
- Back
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What are the pathogen responsibility for CD8 CTL, CD4 TH1, and CD4 TH2?
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1. CD8 CTL - viruses, intracellular pathogens, MHC I presenting
2. CD4 TH1 - bacteria, extracellular, MHC II presenting 3. CD4 TH2 - antibody stimulating, extracellular parasites |
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What cytokines produce TH1 and TH2?
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IFN-gamma -> TH1 -> IFN-gamma
IL-4 -> TH2 -> IL-4, IL-5 |
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What are the main players of cell-mediated reactions?
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TH1
macrophage CD8 CTL NK cells producing IFN-gamma, TNF-alpha and TNF-beta |
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What type of cells cause delayed type hypersensitivity?
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macrophage which can form granulomas
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How are macrophages activated?
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CD40:CD40L
IFN-gamma Ag presentation |
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How do macrophage kill bugs?
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oxygen-dependent
oxygen-independent |
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How are CTLs activated?
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1. TCR:peptide/MHCI
2. CD28:B7 3. IL-2 |
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How do CTLs kill bugs?
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perforins, granzymes, Fas/FasL causing apoptosis, cytokines IFN-gamma, TNF-alpha, TNF-beta
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How are NK cells activited?
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IFN-alpha and IFN-beta (secreted by virally infected cells), IL-12 (secreted by phagocytes during TH1 response), IFN-gamma (secreted by TH1 cells)
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How is NK disabled?
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MHC I binding inhibits NK cells, yo
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How do NK cells kill bugs?
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perforin and granzyme
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What does antibody-dependent cell-mediated cytotoxicity involve?
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any cells that expresses Fc receptors to receive IgG Fc region. these cells include NK cells, macrophages, monocytes, neutrophils, and eosinophils
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What cells initiate cell mediated immunity?
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TH1
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*What type of pathogens are involved with humoral response?*
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extracellular response with TH2 initiation of B cells
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What cytokines does TH2 secrete?
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IL-4, IL-5, IL-6, IL-10
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