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21 Cards in this Set
- Front
- Back
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bernard-soulier syndrome
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defect in GpIb receptor on platelet so that platelet cannot bind or identify von Willebrand factor
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glanzmann thrombasthenia
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defect in GpIIb-IIIa receptor on platelet so that fibrinogen cannot bind and platelet plug cannot be secured
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von Willebrand disease
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vWF defect where it is not expressed so platelets don't know where to bind to form plug
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point of coagulation cascade
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production of thrombin in order to convert fibrinogen to fibrin
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intrinsic pathway of coagulation initiation of pathway
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hageman factor (factor XII)
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point of fibrinolytic system?
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plasmin to breakdown fibrin to remove clot when healing is done
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relative size of hemorrhage
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petechiae < pupura (>3mm) < echymoses (>1cm)
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alpha granules
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granules in platelets that have P-selectin and a ton of clotting factors
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dense bodies
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granuels in platelets that contain chemical support for clotting factors (histamine, ADP, ATP, Ca)
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what two molecules are necessary for primary plug
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ADP, thromboxane A2
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Factor V leiden, prothrombin gene mutation
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hypercoagulation factors
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HIT Syndrome (Heparin-Induced Thrombocytopenia)
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Ab formed against heparin and excessive coagulation in limbs
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Lines of Zahn
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histological layers of platelets and fibrin found in thrombus
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thrombus vs postmortem clot?
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thrombus - firm, lines of Zahn
postmortem clot - red jelly, chicken fat-like material |
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Pulmonary embolism cause?
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deep vein thromboses in leg
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decompression sickness
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nitrogen dissolved in blood because of rushed ascension. Caisson disease is chronic form of this disease. gas emboli.
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shock
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cardiovascular collapse involving hypotension, impaired tissue perfusion, hypoxia
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types of shock
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cardiogenic - heart is broke
hypovolemic shock - not enough blood septic shock - bacterial infection |
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cytokine mediator causing shock?
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TNF
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cause of infarcts?
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thrombotic or embolic occlusion of artery or vein
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white (anemic) infarct
red (hemorrhagic) infarct |
white - occlusion of artery with one input
red - occlusion of vein with system with more than one input |
