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31 Cards in this Set
- Front
- Back
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Blood disorder characterized by elevations in blood cholesterol levels.
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Hyperlipidemia
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What are the major plasma lipids?
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Cholesterol
Triglycerides Phospholipids |
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What is a naturally occurring substance that's required by the body to synthesize bile acids and steroid hormones and to maintain the integrity of cell membranes
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Cholesterol
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Cholesterol is found primarily in the (cells or circulation/serum)
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Cells
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Name a bile acid resin, and give the dosage range
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Welchol 3.75 g daily
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Another name for HMG-CoA Reductase Inhibitor
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Statins
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Most heavily used class of lipid-lowering drugs
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Statins
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First available statin in 1987.
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Lovastatin (Mevacor)
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For patients who require significant lowering of triglyceride levels, what should be used?
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Niacin or fibric acid
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The statins block the conversion of HMG-CoA to what?
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Mevalonate
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Blocking the production of cholesterol in the liver leads to (increase/decrease) in the number of LDL cholesterol receptors in the (pancreas/liver)
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Increase
Liver |
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Atorvastatin (Lipitor) and rosuvastatin (Crestor) can lower LDL levels up to __ at max doses
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60%
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Another name for HMG-CoA Reductase Inhibitor
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Statins
|
|
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Most heavily used class of lipid-lowering drugs
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Statins
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First available statin in 1987.
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Lovastatin (Mevacor)
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For patients who require significant lowering of triglyceride levels, what should be used?
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Niacin or fibric acid
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The statins block the conversion of HMG-CoA to what?
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Mevalonate
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Blocking the production of cholesterol in the liver leads to (increase/decrease) in the number of LDL cholesterol receptors in the (pancreas/liver)
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Increase
Liver |
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Atorvastatin (Lipitor) and rosuvastatin (Crestor) can lower LDL levels up to __ at max doses
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60%
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Most common adverse event that occurs with the statins is asymptomatic what?
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elevations in liver function tests (LFT)
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How often should LFT's be checked after starting statin therapy?
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baseline (before starting therapy)
6 and 12 weeks after starting or titrating therapy |
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Therapy should be discontinued if three consecutive tests disclose values that are 4-5 times above normal limits.
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False. Discontinue therapy if 2 consecutive tests disclose values that are 2-3 times above normal limits
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Muscle pain and weakness after taking statins
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Myopathy
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Statin doseages need to be adjusted during pregnancy
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False. Statins are contraindicated during pregnancy
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Bile acid resins bind bile acids in the intestine, creating a soluble complex that circulates throughout the body.
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False. Bile acid resins. Create an insoluble compound that's excreted via feces
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Because bile acid resins bind bile acids in the intestines, less cholesterol returns to the liver.
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True
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The liver makes fewer cholesterol (LDL) receptors because of bile acid binding
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False. Makes more LDL receptors
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With more LDL receptors in the liver due to bile acid binding, the liver takes up more LDL cholesterol, leading to decreased levels in the bloodstream. What is a negative affect of bile acid binding?
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Increased production of VLDL particles
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What does an increase in VLDL levels lead to?
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Increased triglyceride levels
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With bile acid resins, max effects are seen in _ weeks
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3
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Bile acid resins are contraindicated in what conditions?
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Biliary obstruction or chronic constipation
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