Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
223 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
enflurane |
|
|
|
|
etomidate |
|
|
|
|
☆ ketamine |
|
|
|
|
thiopental |
|
|
|
|
☆ alprazolam |
|
• 8-chloro-1-methyl-6-phenyl-4H-triazolobenzodiazepine • 2-amino-5-chloro-benzophenone 원료 • glycine ethyl ester 원료 • acetylhydrazine 원료 |
|
|
☆ lorazepam |
|
• (RS)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
• 링A - 방향성고리 필요. 7번에 EWG 도입시 활성유지. 6,8,9번에 EWG 도입시 활성상실. • 링B - 1번 치환기는 활성과 무관하지만 bulky하면 친화력↓. 2번에 proton acceptor(carbonyl,sulfinyl)필요. 3번에 hydroxyl 도입시 대사 빠르고 ester화 가능. 4,5번 이중결합 포화시 친화력↓ • 링C - 수용체 결합에 필요한 구조는 아님. 입체적으로 도움. 2’에 EWG 도입시 활성유지. 4’에 EWG 도입시 활성감소. 링C는 heteroaromatic, cycloalkenyl 가능.
• 2-(2-chlorobenzoyl)-4-chloroaniline 원료 • diethyl-2-aminomalonate 원료 |
|
|
☆ zolpidem |
|
• N,N-dimethyl-2-(6-methyl-2-p-tolylimidazopyridin-3-yl)acetamide
• Mannich reaction • 4-Methylphenacetyl bromide 원료 • 2-amino-5-methylpyridine 원료 |
|
|
☆ phenobarbital |
|
• 5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione
• 5,5-, 1,5,5- 치환만 수면·항불안·마취 효능 • 5-, 1,3-, 1,3,5,5- 는 불활성 또는 경련유발 • pH 에 따라 3개의 lactam group이 lactim으로 변화 • 5번 탄소 치환기의 탄소수↑, 질소 치환기의 탄소수↑ : 지용성↑ • N에 큰 알킬기는 경련유발, N1, N3모두 치환시 불활성
• 2-phenybutyronitrile 원료 • benzyl cyanide(phenylacetonitrile) 원료 • urea(thiopental 제외, barbiturate, trimethadione) 원료 • diethylmalonate 아님! |
|
|
pentobarbital |
|
|
|
|
propofol |
|
|
|
|
chlorpromazine |
|
|
|
|
haloperidol |
|
|
|
|
☆ risperidone |
|
• 4-[2-[4-(6-fluorobenzoisoxazol-3-yl)-1-piperidyl]ethyl]-3-methyl-2,6-diazabicyclodeca-1,3-dien-5-one
• fluorobutyrophenone • 4번 탄소에 3급 아민기 치환 필수 • propyl 사슬 변화시 활성 감소 • carbonyl기 최적
• Friedel-Crafts acylation • N-acylation • Oxime formation • O-arylation • 1,3-Difluorobenzene 원료 • 1-Acetylpiperidine-4-carbonyl chloride 원료 • 2-Aminopyridine 원료 • 3-Acetylbutyrolactone 원료 |
|
|
sulpiride |
|
|
|
|
☆ olanzapine |
|
• 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thienobenzodiazepine
• dibenzodiazepine
• N-arylation • dehydration • propionaldehyde 원료 • malonitrile 원료 |
|
|
chlordiazepoxide |
|
|
|
|
☆ diazepam |
|
• 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
• 링A - 방향성고리 필요. 7번에 EWG 도입시 활성유지. 6,8,9번에 EWG 도입시 활성상실. • 링B - 1번 치환기는 활성과 무관하지만 bulky하면 친화력↓. 2번에 proton acceptor(carbonyl,sulfinyl)필요. 3번에 hydroxyl 도입시 대사 빠르고 ester화 가능. 4,5번 이중결합 포화시 친화력↓ • 링C - 수용체 결합에 필요한 구조는 아님. 입체적으로 도움. 2’에 EWG 도입시 활성유지. 4’에 EWG 도입시 활성감소. 링C는 heteroaromatic, cycloalkenyl 가능.
• Friedel-Crafts acylation • 2-amino-5-chloro-benzophenone 원료 • glycine ethyl ester 원료 • 2-Amino-5-chlorobenzoic acid 원료 • benzoyl chloride 원료 |
|
|
phenytoin |
|
|
|
|
☆ carbamazepine |
|
• 5H-dibenzoazepine-5-carboxamide • Wohl Ziegler reaction (radical reaction) • 2-nitrotoluene 원료 • phosgen 원료 |
|
|
☆ valproic acid |
|
• 2-propylpentanoic acid
• Retro-Claisen reaction • diethyl malonate 원료 • n-propyl bromide 원료 • ethyl acetoacetate 원료 |
|
|
☆ lamotrigine |
|
• 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
• Grignard reaction • 2,3-dicholoro-1-iodobenzene 원료 • 2,3-dichlorobenzoic acid 원료 • dichlorosulfoxide 원료 • Cuprous cyanide 원료 • 2,3-dichlorobenzyl cyanide 원료 • aminoguanidine 원료 |
|
|
ethosuximide |
|
|
|
|
amitriptyline |
|
|
|
|
clomipramine |
|
|
|
|
imipramine |
|
|
|
|
fluoxetine |
|
|
|
|
paroxetine |
|
|
|
|
sertraline |
|
|
|
|
venlafaxine |
|
|
|
|
trazodone |
|
|
|
|
amphetamine |
|
|
|
|
methylphenidate |
|
|
|
|
modafinil |
|
|
|
|
theophylline |
|
|
|
|
fentanyl |
|
|
|
|
methadone |
|
|
|
|
pentazocine |
|
|
|
|
naloxone |
|
|
|
|
levodopa |
|
|
|
|
carbidopa |
|
|
|
|
selegiline |
|
|
|
|
ropinirole |
|
|
|
|
biperiden |
|
|
|
|
baclofen |
|
|
|
|
cyclobenzaprine |
|
|
|
|
donepezil |
|
|
|
|
acetylcholine chloride |
|
|
|
|
neostigmine |
|
|
|
|
atropine |
|
|
|
|
tropicamide |
|
|
|
|
ipratropium |
|
|
|
|
scopolamine |
|
|
|
|
homatropine |
|
|
|
|
dicyclomine |
|
|
|
|
cyclopentolate |
|
|
|
|
epinephrine |
|
|
|
|
norepinephrine |
|
|
|
|
phenylephrine |
|
|
|
|
salbutamol |
|
|
|
|
bambuterol |
|
|
|
|
ephedrine |
|
|
|
|
terazosin |
|
|
|
|
alfuzosin |
|
|
|
|
propranolol |
|
|
|
|
atenolol |
|
|
|
|
bisoprolol |
|
|
|
|
carvedilol |
|
|
|
|
serotonin |
|
|
|
|
sumatriptan |
|
|
|
|
ondansetron |
|
|
|
|
quetiapine |
|
|
|
|
ropivacaine |
|
|
|
|
bupivacaine |
|
|
|
|
lidocaine |
|
|
|
|
sildenafil |
|
|
|
|
vardenafil |
|
|
|
|
roflumilast |
|
|
|
|
cilostazol |
|
|
|
|
fenoterol |
|
|
|
|
formoterol |
|
|
|
|
beclometasone dipropionate |
|
|
|
|
hydrocortisone-17-butylate |
|
|
|
|
methylprednisolone |
|
|
|
|
prednisolone |
|
|
|
|
montelukast |
|
|
|
|
digitoxin |
|
|
|
|
digoxin |
|
|
|
|
milrinone |
|
|
|
|
amiodarone |
|
|
|
|
sotalol |
|
|
|
|
verapamil |
|
|
|
|
diltiazem |
|
|
|
|
nifedipine |
|
|
|
|
amlodipine |
|
|
|
|
nimodipine |
|
|
|
|
acetazolamide |
|
|
|
|
hydrochlorothiazide |
|
|
|
|
furosemide |
|
|
|
|
spironolactone |
|
|
|
|
captopril |
|
|
|
|
enalapril |
|
|
|
|
benazepril |
|
|
|
|
ramipril |
|
|
|
|
lisinopril |
|
|
|
|
losartan |
|
|
|
|
candesartan |
|
|
|
|
irbesartan |
|
|
|
|
valsartan |
|
|
|
|
telmisartan |
|
|
|
|
methyldopa |
|
|
|
|
levodopa |
|
|
|
|
hydralazine |
|
|
|
|
simvastatin |
|
|
|
|
pravastatin |
|
|
|
|
atorvastatin |
|
|
|
|
fluvastatin |
|
|
|
|
rosuvastatin |
|
|
|
|
ezetimibe |
|
|
|
|
clofibrate |
|
|
|
|
gemfibrozil |
|
|
|
|
bezafibrate |
|
|
|
|
acipimox |
|
|
|
|
orlistat |
|
|
|
|
warfarin |
|
|
|
|
dipyridamole |
|
|
|
|
ticlopidine |
|
|
|
|
clopidogrel |
|
|
|
|
exenatide |
|
|
|
|
liraglutide |
|
|
|
|
sitagliptin |
|
|
|
|
saxagliptin |
|
|
|
|
vildagliptin |
|
|
|
|
glibenclamide |
|
|
|
|
glimepiride |
|
|
|
|
repaglinide |
|
|
|
|
nateglinide |
|
|
|
|
metformin |
|
|
|
|
acarbose |
|
|
|
|
miglitol |
|
|
|
|
voglibose |
|
|
|
|
cortisol |
|
|
|
|
estradiol |
|
|
|
|
estriol |
|
|
|
|
raloxifene |
|
|
|
|
medroxyprogesterone |
|
|
|
|
finasteride |
|
|
|
|
levothyroxine |
|
|
|
|
propylthiouracil |
|
|
|
|
alendronate |
|
|
|
|
acetaminophen |
|
|
|
|
aspirin |
|
|
|
|
indomethacin |
|
|
|
|
diclofenac |
|
|
|
|
dexibuprofen |
|
|
|
|
ketoprofen |
|
|
|
|
naproxen |
|
|
|
|
piroxicam |
|
|
|
|
celecoxib |
|
|
|
|
probenecid |
|
|
|
|
allopurinol |
|
|
|
|
histamine |
|
|
|
|
azelastine |
|
|
|
|
cetirizine |
|
|
|
|
fexofenadine |
|
|
|
|
ketotifen |
|
|
|
|
loratadine |
|
|
|
|
cimetidine |
|
|
|
|
nizatidine |
|
|
|
|
ranitidine |
|
|
|
|
lansoprazole |
|
|
|
|
esomeprazole |
|
|
|
|
p-aminobenzoic acid |
|
|
|
|
sulfamethoxazole |
|
|
|
|
sulfadiazine |
|
|
|
|
ofloxacin |
|
|
|
|
ciprofloxacin |
|
|
|
|
penicillin G benzathin |
|
|
|
|
amoxicillin |
|
|
|
|
bacampicillin |
|
|
|
|
pivmecillinam |
|
|
|
|
cephalosporin |
|
|
|
|
cefaclor |
|
|
|
|
cefadroxil |
|
|
|
|
cefdinir |
|
|
|
|
cefixime |
|
|
|
|
chloramphenicol |
|
|
|
|
chloroquine |
|
|
|
|
mefloquine |
|
|
|
|
pyrimethamine |
|
|
|
|
artemisinin |
|
|
|
|
metronidazole |
|
|
|
|
ketoconazole |
|
|
|
|
fluconazole |
|
|
|
|
terbinafine |
|
|
|
|
griseofulvin |
|
|
|
|
isoniazid |
|
|
|
|
p-aminosalicylic acid |
|
|
|
|
pyrazinamide |
|
|
|
|
dapsone |
|
|
|
|
clofazimine |
|
|
|
|
zidovudine |
|
|
|
|
lamivudine |
|
|
|
|
nevirapine |
|
|
|
|
penciclovir |
|
|
|
|
famciclovir |
|
|
|
|
acyclovir |
|
|
|
|
valacyclovir |
|
|
|
|
oseltamivir |
|
|
|
|
nitrogen mustard |
|
|
|
|
cyclophosphamide |
|
|
|
|
carmustine |
|
|
|
|
mitomycin C |
|
|
|
|
cisplatin |
|
|
|
|
methotrexate |
|
|
|
|
mercaptopurine |
|
|
|
|
5-fluorouracil |
|
|
|
|
gemcitabine |
|
|
|
|
daunorubicin |
|
|
|
|
topotecan |
|
|
|
|
bleomycin |
|
|
|
|
paclitaxel |
|
|
|
|
tamoxifen |
|
|
|
|
imatinib |
|
|
