ROP is a multifactorial disease. Low gestational age, low birth weight, sepsis, oxygen therapy, respiratory distress syndrome, and blood transfusion have been suspected to influence the incidence of ROP. The most significant risk factors for development of ROP were low gestational age and low birth weight, as shown in many studies. In our study, low gestational age, sepsis, oxygen therapy, and frequency of blood transfusions were found to be risk factors for development of ROP independently. Meanwhile, sex, mode of delivery, birth weight, respiratory distress syndrome, patent ductus arteriosus, intraventricular hemorrhage, hypotension, phototherapy, duration of oxygen therapy, mechanical ventilation, and CPAP were nonsignificant risk factors
