Muscle Contraction

Decent Essays
II.I How it is use?
Muscle contraction requires the use of ATP molecules. Indeed, muscle cells are composed of contractile elements: sarcomeres. Muscle contraction is due to the slippage of myosin fibers on the actin fibers. For this, the head of the myosin binds to the troponin site of the actin filament. Then, an ATP molecule will bind to myosin to separate actin and myosin and thus allow its attachment to the neighboring troponin site due to hydrolysis of ATP in ADP + Pi.
This creates a slippage of myosin fibers on the actin fibers and allows for muscle contraction.
However, one molecule: tropomyosin binds to the troponin sites present on the actin filaments and thus prevents attachment of myosin fibers to the actin fibers:this allows muscle relaxation. In order
…show more content…
This entry of calcium is due to the reception of a nervous signal.
A large amount of ATP must therefore be synthesized rapidly and continuously in order to allow muscle contraction.
During a physical effort, the first system implemented is the anaerobic system. It includes the use of ATP already present in the muscles which allows 2 seconds of muscle contraction, as we saw before in the introduction. Then hydrolysis of phosphocreatine allows 30 seconds of contraction and regenerates some ATP. However, muscle requires continuous production of
ATP throughout the duration of physical exercise. There is therefore another anaerobic means: anaerobic glycogenolysis. It is placed at the beginning of the effort and allows the formation of 3 molecules of ATP from a molecule of glycogen and forms 2 molecules of lactic acid which will hydrolyze in protons H + and anion lactate . During intense and short-term exercise, when proton transport shuttle systems begin to be exceeded, H + ions by combining with pyruvic acid form lactic acid, which causes accumulation of the lactate in the cytosol .In addition, when exercise increases in intensity and duration an ammonium

Related Documents

  • Improved Essays

    Cellular Respiration

    • 767 Words
    • 4 Pages

    During strenuous exercise, such as lifting, muscles require glucose (and glycogen) as fuel faster than oxygen can be provided. Oxygen is important because it helps to do the lifting. Your muscles go into anaerobic cellular respiration because of low oxygen which causes lactate fermentation (lactide acid) to form. This is evident in the beginning of stage 2 because of the burning or aching sensation in the muscle fibres. During lactate fermentation in cells, the pyruvate which was produced during glycolysis is converted to lactide acid by oxidizing an electron…

    • 767 Words
    • 4 Pages
    Improved Essays
  • Decent Essays

    The reasons why kidney and skeletal muscle chosen for the kinetic analysis of LDH: Lactate dehydrogenase (LDH) is the enzyme that coverts high level lactate to pyruvate and maintain equilibrium level in skeletal muscle. In the abive case Lactate dehydrogenase action is completely correlated to the muscular fatigue. The production of lactic acid during severe excerise or heavy work load is leading to muscle fatigue. Normally at rest means the excess lactate converted to pyruvate . Usually LDH reduces lactate level by various ways by generating NAD+ with glyceradehyde -3-phophate and also by promoting ATP energy production through second period of glycolytic phase to the muscle cells under heavy work loads in skeletal muscle.…

    • 382 Words
    • 2 Pages
    Decent Essays
  • Decent Essays

    4. Wave summation occurs with the muscle are stimulated rapidly without rest in-between the stimulus. The failure to remove the calcium before each stimulus causing the calcium to build up in the sarcoplasm and creating multiple power stroke of the myosin and actin. The MMU, the multiple motor neuron, is a stimulation of a whole group of muscle nerves.…

    • 421 Words
    • 2 Pages
    Decent Essays
  • Improved Essays

    They are essential for the proper folding of thick filament myosin during myofibrillogenesis. Therefore, a decrease in these two specific molecular chaperones "results in the destabilization and degradation of their client protein myosin" (Barral et al., 1998; Hawkins et al., 2008; Landsverk et al., 2007). When myosin cannot fold properly into its functional state, sarcomere formation is disrupted because of the importance that myosin has in maintaining organizational structure. A representational image of a sarcomere is shown above in Fig 4., and myosin 's importance is clearly seen as it forms the thick filaments that hold the sarcomeric unit together. This undeniable importance not only arises from the fact that myosin is the main molecular motor involved in muscle contraction, but also because of its structural formation from cross-linking in the M-line and its attachment to the Z-line through the elastic protein,…

    • 1340 Words
    • 5 Pages
    Improved Essays
  • Improved Essays

    The firing of gamma motor neurons in sync with alpha motor neurons pulls muscle spindles, innervating the muscle. The spindle is innervated by type Ia sensory fiber that goes on to synapse with alpha motor units. Therefore, there are more motor units being put to work and the type 1a afferents maintain their sensitivity.…

    • 399 Words
    • 2 Pages
    Improved Essays
  • Improved Essays

    Ideally, a fast heart rate recovery shows that the body is functioning at the optimum level. High intensity anaerobic exercises typically cause high post-exercise oxygen uptake because the body is incapable of providing adequate oxygen during the physical activity. However, prior entering the Krebs Cycle, the insufficient activation of the pyruvate dehydrogenase complex (PDC) prevents pyruvate from converting to acetyl coenzyme A. The deficiency of PDC inhibits the Krebs Cycle and thus limits the amount of oxygen produced. The Krebs Cycle is a complex series of reactions that living organisms use to produce energy.…

    • 984 Words
    • 4 Pages
    Improved Essays
  • Improved Essays

    Muscle Sumation Lab Report

    • 1843 Words
    • 8 Pages

    his lab report discussed and elaborated how muscle contraction is an intricate and precise step-by-step process in the body. The concepts outlined at the introduction intertwine with the experiments performed in this lab. The experiments aimed to showcase the physiological cause and effect of skeletal muscle response towards various situations. For instance, the first experiment demonstrated spatial summation through the form of muscle recruitment. The cause of this reaction was due to the increased voltage stimulus on the sciatic nerve.…

    • 1843 Words
    • 8 Pages
    Improved Essays
  • Improved Essays

    In class, we’ve talked about the myosin when seeing the microfilament. It is the motor protein of microfilament which moves along it tracks toward the positive end. It is also the major component of skeletal muscle thick filaments and thus, is involved in muscle contraction. The disease that is going to discuss is related to muscle contraction, called Myosin Storage Myopathy (also known as hyaline body myopathy).…

    • 574 Words
    • 3 Pages
    Improved Essays
  • Decent Essays

    When acetyl-CoA enters the cycle, and the acetate (two carbons) is combined with the four-carbon molecule oxaloacetate. Citrate is then produced which is rearranged to isocitrate. In the first oxidation, isocitrate is oxidized to 2-oxoglutarate (α-ketoglutarate) in which a carbon is lost as CO2 and NAD+ reduced to NADH. In the second oxidation, 2-oxoglutarate is converted to succinyl-CoA leaving carbon as CO2 and NAD+ reduced to NADH. The product is attached to coenzyme A and reaction is catalyzed by oxoglutarate dehydrogenase.…

    • 216 Words
    • 1 Pages
    Decent Essays
  • Improved Essays

    The myosin is now ready to form another crossbridge and the cycle of contraction will continue until the impulse stops. 9. Once the impulse stops, Calcium is released from troponin causing tropomyosin to cover the binding sites and prevent…

    • 491 Words
    • 2 Pages
    Improved Essays
  • Improved Essays

    This causes the release of acetylcholine in the vesicles into neuromuscular junction. Acetylcholine is an excitatory neurotransmitter that binds to the acetylcholine receptors on the muscle, This opens the sodium channels that depolarize the muscle fiber. Depolarization of the muscle continues along the membrane and then down into the T-tubules, which is continuous with muscle fiber’s membrane. The depolarization activates dihydropyridine receptors on T-tubule and causes calcium release from the linked ryanodine receptors on sarcoplasmic reticulum. Calcium is released from ryanodine receptors and triggers muscle contraction by exposing the binding site on actin to allow cross bridges to form between actin and myosin (Sherwood, 2010,…

    • 654 Words
    • 3 Pages
    Improved Essays
  • Improved Essays

    Smooth muscle cells lack the striation component that aligns contractile units. The cells are filled with dense bodies that allow binding of contractile units. Actin filaments project from one end of the dense bodies. Suspended in between the actin are the thick myosin filaments. When the smooth muscle is stimulated to contract, the myosin filaments will start inching toward the actin, resulting in the shortening of fibers.…

    • 537 Words
    • 3 Pages
    Improved Essays
  • Improved Essays

    Muscles are often only described by large features and classified by a particular region of group of muscles, which does not do the complexity muscle tissue justice. When a skeletal muscle cell is broken down on a microscopic level one is able to truly grasp just how intricate skeletal muscles are along with how they function on a physiological level. Skeletal muscle cells cannot be understood until three key aspects of their structure are enumerated and these are their myofibrils, sarcoplasmic reticulum and t-tubules. To start the myofibrils are the column like structures that run laterally through the inside of the sarcolemma. These rod-like myofibrils are very tightly packed together and are the structures that contract muscles thusly accounting…

    • 296 Words
    • 2 Pages
    Improved Essays
  • Great Essays

    Cilia Essay

    • 1214 Words
    • 5 Pages

    Cilia and the Protection of the Respiratory Tract Introduction Approximately twelve thousand litres of air is inhaled by one person each day containing environmental stimuli including pathogens and particles such as toxic pollutants and allergens. These must be expelled from the body as it may induce airway inflammation and infection, causing airway diseases. Mucociliary clearance acts as an innate defence against these stimuli, where cilia is a part of this mechanism. Cilia, microscopic organelle extensions, beat orderly to propel mucus with embedded substances out of the respiratory system. When this mechanism becomes disrupted, pulmonary infections occur and chronic airway diseases may arise to be severe, emphasising the importance of cilia.…

    • 1214 Words
    • 5 Pages
    Great Essays
  • Improved Essays

    5.0 Discussion 5.1 Adenosine Triphosphate System In touch football there are three systems used throughout the duration of the game these are the ATP system (Adenosine Triphosphate), the Lactic Acid system (anaerobic glycolysis) and the final system the Aerobic system. ATP doesn’t exist in the muscles and tissues waiting to supply abundant amounts of energy (Hede, Russell and Weatherby), ATP is a chain consisting of three phosphate groups. To produce energy the phosphate chain breaks and one phosphate group is broken off to produce this energy needed for movement. In breaking the phosphate chain, energy is used to allow the production of energy as the end product (Personal training direct, 2014).…

    • 1109 Words
    • 4 Pages
    Improved Essays