GENTAMICIN
The drug selected for study is Gentamicin. Gentamicin is an aminoglycoside antibiotic composed of a mixture of related Gentamicin components and fractions and is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms. Isolation and Preliminary studies 2 demonstrated that it is a mixture of basic, water soluble antibiotic containing the aminocyclitol 2-deoxystreptamine and two additional amino sugars. Chromatographic separation of Gentamicin complex that is consists of c1, c2 and c1a. The gentamicin is used as the sulphate salt in various dosage forms (Vydrin et al., 2013).
3.1.1 Category : Aminoglycoside antibiotics
3.1.2 Chemical Structure :
The structures of Gentamicin are following (Fig. 3.1) Fig 3.1: Structure of Gentamicin
3.1.3 Chemical name : (3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)- 3-amino-6-[(1R)-1-(methylamino)ethyl]oxan-2-yl]oxy}-2- …show more content…
and topically.
3.2.4 Adverse drug reactions
Nephrotoxic - tubular necrosis, probably related to interference in the phospholipids metabolism in proximal tubular cells lysosomes with resultant leakage of proteolytic enzyme into the cytoplasm. Ototoxic – (Toxicity of the 8th cranial nerve).
3.2.5 Indications and uses
Active against a wide range of human bacterial infections, mostly Gram-negative bacteria including Pseudomonas, Proteus, Serratia, and the Gram-positive Staphylococcus. Gentamicin is not used for Neisseria gonorrhoeae, Neisseria meningitidis or Legionella pneumophila bacterial infections (because of the risk of the patient going into shock from lipid A endotoxin found in certain Gram-negative organisms). Gentamicin is also useful against Yersinia pestis, its relatives, and Francisella tularensis (the organism responsible for Tularemia seen often in hunters and/or trappers).
3.2.6
The drug selected for study is Gentamicin. Gentamicin is an aminoglycoside antibiotic composed of a mixture of related Gentamicin components and fractions and is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms. Isolation and Preliminary studies 2 demonstrated that it is a mixture of basic, water soluble antibiotic containing the aminocyclitol 2-deoxystreptamine and two additional amino sugars. Chromatographic separation of Gentamicin complex that is consists of c1, c2 and c1a. The gentamicin is used as the sulphate salt in various dosage forms (Vydrin et al., 2013).
3.1.1 Category : Aminoglycoside antibiotics
3.1.2 Chemical Structure :
The structures of Gentamicin are following (Fig. 3.1) Fig 3.1: Structure of Gentamicin
3.1.3 Chemical name : (3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)- 3-amino-6-[(1R)-1-(methylamino)ethyl]oxan-2-yl]oxy}-2- …show more content…
and topically.
3.2.4 Adverse drug reactions
Nephrotoxic - tubular necrosis, probably related to interference in the phospholipids metabolism in proximal tubular cells lysosomes with resultant leakage of proteolytic enzyme into the cytoplasm. Ototoxic – (Toxicity of the 8th cranial nerve).
3.2.5 Indications and uses
Active against a wide range of human bacterial infections, mostly Gram-negative bacteria including Pseudomonas, Proteus, Serratia, and the Gram-positive Staphylococcus. Gentamicin is not used for Neisseria gonorrhoeae, Neisseria meningitidis or Legionella pneumophila bacterial infections (because of the risk of the patient going into shock from lipid A endotoxin found in certain Gram-negative organisms). Gentamicin is also useful against Yersinia pestis, its relatives, and Francisella tularensis (the organism responsible for Tularemia seen often in hunters and/or trappers).
3.2.6