Gas gangrene belongs to the genus Clostridium (Carlisle 2014). It’s a non-motile, gram-positive, anaerobic, and spore-forming bacillus (Carlisle 2014). The most common etiologic agent that causes gas gangrene is called Clostridium perfringes. This can enter your body through open wounds and eating poorly cooked meat. Since C. perfringes is an anaerobic bacterium, it uses energy by using anaerobic respiration and Nitrate as an electron acceptor. When the bacterium is around Nitrate, it will increase its growth. It also can through a process called anaerobic fermentation. It produces gases that could add to its survival by constructing an anaerobic habitat in the host’s tissues.
Once diagnosis is confirmed, treatment should be given right away. Back in the day, penicillin G in dosages of 10-24 million U/d was the drug of choice (Ho …show more content…
Nowadays, using both penicillin and clindamycin is widely used. According to the World Health Organization, they recommend taking Penicillin G and metronidazole for 5-7 days. For an adult, taking IV 1 – 5 MIU every 6 hours and after 2 days, you can take 2 Penicillin V tablets every 6 hours. While taking that, you also take IV 500 mg of Metronidazole every 8 hours which should be infused over 20 minutes. There are patients who are allergic to penicillin so they would just substitute it with a combination of clindamycin and metronidazole. But before antibiotics are given, they first drain the wound and remove infected tissues to prevent the spreading of infection (Carlisle 2014). The mechanism of action of the drug, penicillin G, is during active multiplication the synthesis of cell wall multiplication outcomes in bactericidal activity against susceptible
Once diagnosis is confirmed, treatment should be given right away. Back in the day, penicillin G in dosages of 10-24 million U/d was the drug of choice (Ho …show more content…
Nowadays, using both penicillin and clindamycin is widely used. According to the World Health Organization, they recommend taking Penicillin G and metronidazole for 5-7 days. For an adult, taking IV 1 – 5 MIU every 6 hours and after 2 days, you can take 2 Penicillin V tablets every 6 hours. While taking that, you also take IV 500 mg of Metronidazole every 8 hours which should be infused over 20 minutes. There are patients who are allergic to penicillin so they would just substitute it with a combination of clindamycin and metronidazole. But before antibiotics are given, they first drain the wound and remove infected tissues to prevent the spreading of infection (Carlisle 2014). The mechanism of action of the drug, penicillin G, is during active multiplication the synthesis of cell wall multiplication outcomes in bactericidal activity against susceptible