CRITICAL REVIEW ON TREATMENT AND PREVETION OF HEPATIC CIRRHOSIS AND FIBROSIS
INTRODUCTION
Liver cirrhosis is a common outcome in clinical progressions of all chronic liver diseases, distinguished by substitution of tissues of the liver by fibrous (scar) tissues. Regenerative nodules - lumps that appear in a bid to repair the damaged tissues – also replace the liver tissues, leading to an alteration of the liver structure to into structurally abnormal nodules. Liver fibrosis is as a resultant effect of the propagation of the process of healing of wounds, leading to fibrogenesis - an uncharacteristic obstinate process of connective tissue production and removal (Anthony, 1978).
It has been reported that cirrhosis occurs in roughly 20 % of individuals diagnosed with Hepatitis C Virus (HCV). But, this statistic is gotten from risk evaluations after 20 years of infection (Fattovich et al., 1997). And because HCV contraction can occur early in life through either contaminated medical equipment or injection drug usage, this makes the duration of infection often much longer than 20 years. Patterning data indicate that the risk of cirrhosis may surpass 40 % by 30 years of infection (Thein et al., 2008); nonetheless, exact data on the lifetime risk of cirrhosis are lacking. As regards potential hosts, age when infected are imperative with the …show more content…
The cirrhotic liver 's rigidity can give investigative information on the site and acuteness of cirrhosis. Techniques used include “transient elastography, acoustic radiation force impulse imaging, supersonic shear imaging and magnetic resonance elastography”. Compared to a biopsy, elastography can test a broader section of the liver and is unproblematic. It also shows considerable connection with the seriousness of cirrhosis. Other tests executed in specific situations comprise abdominal Computerized Tomography scan and liver/bile duct MRI scan (Foucher et al.,
INTRODUCTION
Liver cirrhosis is a common outcome in clinical progressions of all chronic liver diseases, distinguished by substitution of tissues of the liver by fibrous (scar) tissues. Regenerative nodules - lumps that appear in a bid to repair the damaged tissues – also replace the liver tissues, leading to an alteration of the liver structure to into structurally abnormal nodules. Liver fibrosis is as a resultant effect of the propagation of the process of healing of wounds, leading to fibrogenesis - an uncharacteristic obstinate process of connective tissue production and removal (Anthony, 1978).
It has been reported that cirrhosis occurs in roughly 20 % of individuals diagnosed with Hepatitis C Virus (HCV). But, this statistic is gotten from risk evaluations after 20 years of infection (Fattovich et al., 1997). And because HCV contraction can occur early in life through either contaminated medical equipment or injection drug usage, this makes the duration of infection often much longer than 20 years. Patterning data indicate that the risk of cirrhosis may surpass 40 % by 30 years of infection (Thein et al., 2008); nonetheless, exact data on the lifetime risk of cirrhosis are lacking. As regards potential hosts, age when infected are imperative with the …show more content…
The cirrhotic liver 's rigidity can give investigative information on the site and acuteness of cirrhosis. Techniques used include “transient elastography, acoustic radiation force impulse imaging, supersonic shear imaging and magnetic resonance elastography”. Compared to a biopsy, elastography can test a broader section of the liver and is unproblematic. It also shows considerable connection with the seriousness of cirrhosis. Other tests executed in specific situations comprise abdominal Computerized Tomography scan and liver/bile duct MRI scan (Foucher et al.,