Blood-based profile should yield information for clinical events that can be correlated to collected data (38).As blood circulates through every organ and tissue of the body, it contains valuable information pertaining to the different physiological and pathological states of the organism (39). The circulatory system thus provides a unique repertoire of proteins and peptides produced by cells and tissues that trickle into the blood stream and can potentially be used to assess both normal and disease conditions.Hence it is assumed that plasma contain biomarkers for every biological and disease process occurring in the body. For instance, upon myocyte death, cellular proteins are released into the blood where their detection is possible. Furthermore,
