1.4 Effect of Microcrystalline Cellulose (MCC)Type
Formula F12 was utilized to study the effect of changing the type of MCC(Avecil PH-101 ) as a carrier material instead of (Avecil PH-102) in F8 on the dissolution behavior of the prepared Zolmitriptan liquisolid ODTs. Although the DT of formula F12 (79 sec.) was greater than F8 (48 sec.) as in Table(18),the dissolution behavior of the formula F12 was faster than F8 as in Table (18) and Figure (48), this difference was non significant(p>0.05) and resulted from the sensitivity of the F8 to the lubricant magnesium stearate to greater extent more than F12 .The sensitivity of the MCC to the lubricant depends on the particle size ,where F8 contains Avecil PH-102 with mean particle size of …show more content…
When the drug within the liquisolid system is completely dissolved in the liquid vehicle, it is located in the powder substrate still in a solubilized state. Therefore they show improved release rate ,Thus, its release is accelerated due to its markedly increased wettability and surface availability to the dissolution medium(147). Figure (52): A comparison in the dissolution profile of the prepared Zolmitriptan liquisolid ODTs (F18) , marketed Zolmitriptan oral dispersible tablet (Zomig-ZMT_2.5 mg tablet) and DCT-ODT in pH 6.8 phosphate buffer at 37oC. (Results are expressed as mean, n=3)
Table (18): In Vitro Dissolution Parameters of the Liquisolid ODTs of Zolmitriptan in Phosphate Buffer pH 6.8 at
Formula F12 was utilized to study the effect of changing the type of MCC(Avecil PH-101 ) as a carrier material instead of (Avecil PH-102) in F8 on the dissolution behavior of the prepared Zolmitriptan liquisolid ODTs. Although the DT of formula F12 (79 sec.) was greater than F8 (48 sec.) as in Table(18),the dissolution behavior of the formula F12 was faster than F8 as in Table (18) and Figure (48), this difference was non significant(p>0.05) and resulted from the sensitivity of the F8 to the lubricant magnesium stearate to greater extent more than F12 .The sensitivity of the MCC to the lubricant depends on the particle size ,where F8 contains Avecil PH-102 with mean particle size of …show more content…
When the drug within the liquisolid system is completely dissolved in the liquid vehicle, it is located in the powder substrate still in a solubilized state. Therefore they show improved release rate ,Thus, its release is accelerated due to its markedly increased wettability and surface availability to the dissolution medium(147). Figure (52): A comparison in the dissolution profile of the prepared Zolmitriptan liquisolid ODTs (F18) , marketed Zolmitriptan oral dispersible tablet (Zomig-ZMT_2.5 mg tablet) and DCT-ODT in pH 6.8 phosphate buffer at 37oC. (Results are expressed as mean, n=3)
Table (18): In Vitro Dissolution Parameters of the Liquisolid ODTs of Zolmitriptan in Phosphate Buffer pH 6.8 at