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23 Cards in this Set
- Front
- Back
Prostate Cancer treatment (2)
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Leuprolide (continuous)
Flutamide (inhibits androgens binding receptor) |
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Leuprolide mech, uses (2), toxicities
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GnRH analog
uses- infertility (pulsatile), prostate cancer (continuous), uterine fibroids toxicities- N/V, antiandrogen |
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use what to stimulate anabolism to promote recovery after burn/injury
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testosterone
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testosterone effect on:
epiphyseal plates LDL HDL |
can be converted in estrogen by body, can prematurely cloes epiphyseal plates with exogenous use
opposite of estrogen: increase LDL, decrease HDL |
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Flutamide mech
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competitive inhibitor of androgens at testosterone receptor
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ketokonazole mech for antiandrogen effects
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inhibits desmolase (produces androstenedione)
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spironolactone mech for antiandrogen effects
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inhibits steroid binding
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2 drugs that can be used for hirsutism in polycystic ovarian syndrome
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ketoconazole, spironolactone
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4 estrogen administration complications
2 contrindications |
complications- risk of clots, endometrial carcinoma, clear cell adenoarcinoma of vagina (DES in utero), postmenopausal bleeding
Her-2 positive cancer, history of DVTs |
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Clomiphene mech, 2 uses
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partial estrogen agonist, prevents normal inhibition of LH and FSH at hypothalamus--> stimulates ovulation
used for infertility, PCOS |
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2 hormone replacement indications?
additive? |
menopause
osteoporosis add progesterone to avoid endometrial carcinoma possible increased CV risk |
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Anastrozole
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aromatase inhibitor (for postmenopasual breast cancer)
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Exemestane
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aromatase inhibitor (for post-menopausal breast cancer)
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2 uses for progestins
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endometrial cancer, abnormal uterine bleeding
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Mifepristone mech, use, toxicites (3)
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progesterone antagonist
for abortion (with misoprostol) GI effects, abdominal pain, heavy bleeding |
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OCPs decrease incidence of what 3 things?
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endometrial cancer, ovarian cancer, pelvic infections
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5 side effects of OCPs
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high TGs, depression, weight gain, HTN, nausea, hypercoagulable state
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3 contraindications for OCP
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smoker over 35
history of thromboembolism estrogen-dependent tumor |
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Dinoprostone mech, use
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PGE2 analog, induces labor
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Ritodrine mech, use
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B2 agonist
relax uterus to prevent premature contractions "Ritodrine allow fetus to return to dreams" |
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Terbutaline mech, use
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B2 agonist
relaxes uterus, tocolytic |
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Tamulosin receptor action
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alpha 1(a,d) receptor specific (for prostate)
1b is for peripheral vasoconstriction |
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Sildenafil/Vardenafil
4 toxicities 1 contraindication |
toxicities - headache, peptic distress, flushing, impaired blue-green color vision
"Hot and sweaty, but then Headache, Heartburn, Hypotension" DON'T take with Nitrates- severe hypotension |