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89 Cards in this Set
- Front
- Back
a drug which alleviates pain: ?
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Analgesic
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a drug which abolishes/blunts memory or events: ?
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Amnestic
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agent which induces sleep: ?
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Hypnotic
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the onset of the anesthetic: ?
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Induction
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the termination of an anesthetic, when the patient "wakes up": ?
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Emergence
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Nitrous Oxide: drug class
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inhaled anasthetic
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Nitrous Oxide: hypoxia?
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no
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Nitrous Oxide: rate of induction?
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slow
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Nitrous Oxide: respiratory depression
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no
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Nitrous Oxide: cardiac depression
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no
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Ether: drug class
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inhaled anasthetic
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Ether: hypoxia?
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yes
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Ether: rate of induction?
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fast
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Ether: respiratory depression
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yes
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Ether: cardiac depression
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yes
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Chloroform: : drug class
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inhaled anasthetic
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Chloroform: : cardiac depression
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yes
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Chloroform: : hepatic toxicity
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yes
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The Fluorinated Anesthetics: 3 from class
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halothane, isoflurane, sevoflurane
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Halothane : drug class
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inhaled anasthetic
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Halothane : chemistry
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alkane
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Halothane : hepatic toxicity
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just a lil bit
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Halothane : flammable
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no
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Isoflurane, : drug class
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inhaled anasthetic
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Isoflurane, : chemistry
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ether
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Isoflurane, : emergence rate
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slow
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Isoflurane, : cardiovascular efx
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just a lil myocardial depresion; decreased systemic vascular resistance
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Isoflurane, : respiratory efx
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irritates airways; depression
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Isoflurane, : hepatic efx
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no hepatitis
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Sevoflurane: : drug class
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inhaled anasthetic
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Sevoflurane: : chemistry
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ether
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Sevoflurane: : rate of induction?
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fast
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Sevoflurane: : emergence rate
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fast
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Sevoflurane: : blood solubility
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low
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MAC (minimum alveolar concentration): importance to anesthesia
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expression of potency; concentration necessary at 1 atm that prevents movement in 50% subjects from pain
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MAC-BAR: importance to anesthesia
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concentration necessary to Block Adrenergic Response
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Nitrous Oxide: blood solubility
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stupid low
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Nitrous Oxide: odor
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none
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Nitrous Oxide: cardiovascular efx
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minimal depression; increased pulmonary artery pressure
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Nitrous Oxide: respiratory efx
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minimal depression
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Nitrous Oxide: CNS circ efx
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increased cerebral blood flow
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Nitrous Oxide: hematopoietic sx
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megaloblastic anemia is possible (supression of methionine sythetase)
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Halothane : flammable
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no
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Halothane : blood solubility
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moderate
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Halothane : odor
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sweet
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Halothane : cardiovascular efx
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slows heart rate, potentiates epinephrine induced arrythmias, myocardial depression
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Halothane : respiratory efx
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depression
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Halothane : CNS circ efx
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increased cerebral blood flow; decreased cerebral metabolism
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Halothane : musculoskeletal
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promotes relaxation; esp uterine
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Halothane : hepatic efx
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halothane hepatiis; 1:222K anesthetics
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Halothane : renal efx
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decreased GFR and renal flow
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Malignant Hyperthermia: ?
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potentially lethal condition associated with inhaled N2O and succinylcholine
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Malignant Hyperthermia: tx
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dantrolene (blocks Ca into muscles)
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ryanodine receptor : ?
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sarcoplasmic reticulul Ca channel; linked to malignant hyperthermia (anasthesia)
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Barbituates: Cytochrome metabolism
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P450
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Barbituates: counterindx
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porphyria
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Barbituates: respiratory depression
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yup
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Barbituates: cardiac depression
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yup (preserved baroreceptor reflex)
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Pentobarbital : Cytochrome metabolism
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P450
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Pentobarbital : drug class
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barbituate
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Pentobarbital : counterindx
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porphyria
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Pentobarbital : respiratory depression
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yup
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Pentobarbital : cardiac depression
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yup (preserved baroreceptor reflex)
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Pentobarbital : elimination half life
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12 hours
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Pentobarbital : histamine release?
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yes
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Methohexital : drug class
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barbituate
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Methohexital : counterindx
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porphyria
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Methohexital : elimination half life
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4 hours
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Methohexital : histamine release?
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no
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Midazolam : Cytochrome metabolism
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CYP 3A4
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Midazolam : drug class
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benzodiazapine
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Midazolam : active metabolites
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yes
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Midazolam : interax
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competes at CYP 3A4 w/ erythromn; -anil's
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Diazepam: drug class
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benzodiazapine
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Diazepam: active metabolites
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yes
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Lorazepam: drug class
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benzodiazapine
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Lorazepam: active metabolites
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no
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Ketamine:: drug class
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phencyclidines
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Ketamine:: mechanism
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NMDA receptor antagonist
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Ketamine:: hepatic metabolism
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yes
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Ketamine:: intramuscular ok?
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yup
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Ketamine:: clinical use
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battlefield; no resp depression; use when need spontaneous ventilation
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Etomidate : chemistry
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imidazole derivative
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Etomidate : positive aspects
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more rapid awakening than barbitutes; cardiovascular stability
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Etomidate : drawbacks
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nausea; decreased seizure threshold; adrenal supression; myoclonic movements
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Etomidate : eliminatino route
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hepatic
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Etomidate : clinical use
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when hemodynamic stability important
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Propofol : hepatic metabolism
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oh yeah
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Propofol : clinical use
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anesthesia for breif procedures
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