World Health Organization essential medicines

Know One Drug Erin Wu I chose losartan. For your molecule: Note the primary indication, and a secondary indication (even if off label) The primary indication is hypertension. It is also used for diabetic neuropathy and hypertension with left ventricular hypertrophy. Note and be able to draw the pharmacophore that appears to be responsible for activity. Losartan1 valsartan2 The molecule on the left is losartan and the metabolite is on the right. The metabolite is more active than losartan. The pharmacophore is the entire structure of losartan. Note a possible or known change in a sub-structure for the molecule. What functional change(s), if any, results as a consequence of the structural change? (for example, is there a change in activity, potency, distribution, kinetics?) Valsartan. Imidazole is replaced by valine. Increase potency and higher affinity to the receptor. The replacement of valine created an additional hydrogen bonding site to the receptor, which possibly explains the higher affinity to the receptor. In addition, this structural change possibly results in Valsartan having a longer elimination half life of 6 hours, as compared to Losartan, with 1.5-2 hours. This could possibly attribute to the metabolic enzymes taking a longer time to metabolize valsartan due to the carboxylic acid group on it. 14% of Losartan is converted to an active metabolite. An additional…

together in 1945 to create the United Nations, an organization which would encourage cooperation, coordination and provide support to all members of the international system. Shortly after, the UN created of the World Health Organization (WHO), with the aspiration that it would be the leading authority in global health issues for the international system. Since then, the WHO has grown and matured over the years, making important bounds in educating and directing states on important health…

Saving Healthcare Many do not realize how lucky they are to live in a place that has medicine widely available to the public. The author of, “Hospitals targeted across South Sudan” Justin Lynch has reported many articles about the different condition of the people living in South Sudan and how they are suffering due to the failing health care of the country. Justin is currently working for the Associated Press in South Sudan. The destruction of the people’s homes and the hospitals within the…

Comparison of Health Care Systems: United States and Iceland Kamala Sapkota Florida International University Comparison of Health Care Systems: United States and Iceland Introduction For this assignment of comparison of health care systems, I choose Iceland and United States. For a long time I was interested in Iceland as a country itself, I love the weather, the landscapes and wanted to visit one day, this time I had a chance to learn and explore more about its health system and to…

numerous effects on human health. World Health Organization (WHO) has identified that with the reduction of pollution air levels it would also cut down the probability of getting a stroke, heart disease, lung cancer, and both chronic and acute respiratory diseases, including asthma. The groups…

The consumption of unhealthy foods and the lack of physical activity in America have increased drastically since the 1970s, creating health related issues or in the worst case, causing death. As the years go by, Americans have become more dependant on their cars, therefore less people walk to the places they need to go. Also, kids would come home everyday and find a freshly cooked meal, whereas now students go to the nearest fast food restaurant and purchase processed food. This eventually…

capital of Azerbaijan will make the cost of home more expensive do to the fact that the capital it the major part of the country. Houses in Azerbaijan aren’t very expensive but insurance is better. Privatization of communal services to apartment dwellings, homes, and village huts started many years ago. Azerbaijan doesn 't have any homeowners insurance. Homeowners insurance is what is used to protect your home, but Azerbaijan doesn 't have any policy that is supposed to protect your home.…

research article, published in BMC Public Health, discussed the issue of alcohol abuse in many parts of Europe. According to this article, the World Health Organization (WHO) determined Europe to have the highest volume of alcohol consumption in the world. The researchers focused on Ireland and the countries of the United Kingdom because they have the highest levels of binge drinking in Europe and university students have high levels of alcohol consumption in these areas. The researchers…

When you save your right, you can’t hurt others right. People need to respect each other. According to Tobacco Monopoly Law (1991) “The State and society shall intensify the publicity of and education in the fact that smoking is hazardous to health, forbid or restrict smoking on public traffic vehicles and in public places” I very clear support this decide, but I can’t feel good. Now, almost of city cancel smoking room in the Airport and free smoking in the hospital. I don’t know this is happy…

Section Five HUMAN RESOURCE & MARKET ANALYSIS Global/ National Trends: According to Virginia.gov, 1teen pregnancy is a critical public health issue that affects the health, education, social and economic future of mother and child; social issues include welfare dependency, out-of-wedlock births and workforce development. Data shows that 1Virginia (Southwest) (44.7) region had the highest teen pregnancy rates, while the Northern (18.0) region had the lowest. Overall, 1there were 7,335 reported…