Wnt signaling pathway

Introduction: Embryonic stem (ES) cells are pluripotent cells that are derived from the inner cell mass of a blastocyst. These cells have the potential to differentiate into any of the 3 embryonic germ layers, and if cultured properly eventually can become any type of cell within the body. Due to the controversy and ethical concerns regarding the use of ES cells, scientists have discovered a way to generate pluripotent cells, by using Human Induced Pluripotent stem cells (hiPSC).…

what extent Wnt agonist can reverse the behavioral deficits. Lack of such knowledge makes it difficult to design a strategy for ASD risk genes involved in the Wnt pathway. We expect to identify the circuitry defect that is involved in PV neurons specific Ctnnb1 knockout mice and examine the extent to which targeting Wnt pathway would be able to ameliorate the behavioral deficits. This contribution will be significant because it is the critical step to allow control the Wnt signaling pathway in…

wound will activate the Wnt pathway that is necessary for hair follicle regeneration in wounds. Independent variables being tested: The wound size of the mice. Dependent variables being tested: The number of hair follicle. Experimental Design: This experiment will be designed to determine if large wound size, would affect the number of hair follicle. This experiment will have 60 genetically normal Mus musculus and 30 transgenic mice that over express Wnt signaling pathway. A total of 90…

concluded that growth factor 9 enhance Wnt activation that induces hair regeneration after a wound (Gay et al., 2013).…

cofilin aiding to depolymerization by protecting them from being inhibited. Different molecules like neural cell adhesion molecules (N-CAMs), L1 CAMs and N-Cadherin are major proteins that mediates correct axonal navigation by eliciting intracellular signaling within the…

recent years, several studies focused on the investigation of cellular signaling mechanisms underlying HCC development, progression and invasion. In addition to the genetic alterations, chronic liver diseases including HCV infection clearly has a major role in the development and progression of HCC. Because chronic HCV infection is implicated in the modulation of abnormalities in several critical molecular signaling pathways, the attention of clinicians and researchers has focused on the…

Many of the tasks that multi-cellular organisms perform are truly inspiring, from embryogenesis to organogenesis and other developmental processes. Developmental biology covers some of the most interesting procedures of the formation and transformation of living beings. One question in particular that sparked my interest in the vast field is how certain species of animals are able to completely reform a limb after it has been entirely severed. Such a feat is completely and utterly astonishing.…

This mutant humanoid was found performing at a carnival freak show with a sign above him, dubbing him “Lobster Man.” He was cognitively normal and appeared normal except for his hands and feet (Basel, Kilpatrick & Tsipouras 2006; and van Silfhout, et al. 2009). The 1st digits were also normal, but on each hand/foot, digits 2 and 3 looked as if were fused together as were digits 4 and 5. Upon further investigation, it was seen that the 2nd, 3rd, and 4th rays weren’t present at all (Gulia & Marwah…

Introduction All animals can heal their wounds. However, some animals can even regenerate lost body parts. Questions have arisen such as, how does this process take place? What is necessary for these animals to perform this job? Experiments have shown that different animals regenerate in different ways. Some may be similar than others and it may have an impact on their lives. The purpose of regenerating tissues is to limit damage and loss of infection. The processes of tissue regeneration…

INVIVO AND INVITRO STUDIES ON CHEMOPROTECTIVE EFFICACY OF RESVERATROL IN BREAST CANCER 1. INTRODUCTION 1.1 BREAST CANCER: Breast cancer is the most frequently diagnosed cancer and it is one of the leading causes of cancer death in women worldwide. Diet and Nutrition play a key role in carcinogenesis process, as reflected in the global differences in breast cancer incidence worldwide. High fat content, meat and low fiber diets were associated with high breast cancer incidence rates whereas…